Artículo
Mechanisms of adaptation in the intestinal parasite Giardia lamblia
Fecha de publicación:
04/2011
Editorial:
Journal of the Serbian Chemical Society
Revista:
Essays In Biochemistry
ISSN:
0071-1365
e-ISSN:
1744-1358
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Giardia lamblia, a parasite of humans, is a major source of waterborne diarrhoeal disease. Giardia is also an excellent system to study basic biochemical processes because it is a single-celled eukaryote with a small genome and its entire life cycle can be replicated in vitro. Giardia trophozoites undergo fundamental changes to survive outside the intestine of their host by differentiating into infective cysts. Encystation entails the synthesis, processing, transport, secretion and extracellular assembly of cyst wall components. To survive within the intestine, Giardia undergoes antigenic variation, a process by which the parasite continuously switches its major surface molecules, allowing the parasite to evade the host's immune response and produce chronic and recurrent infections. The objective of the present chapter is to provide a better understanding of the molecular mechanisms involved in adaptation and differentiation in Giardia, with a particular focus on the process of encystation and antigenic variation of this interesting micro-organism.
Palabras clave:
Antigenic variation
,
Protein
,
Adaptation
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Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Lujan, Hugo Daniel; Mechanisms of adaptation in the intestinal parasite Giardia lamblia; Journal of the Serbian Chemical Society; Essays In Biochemistry; 51; 1; 4-2011; 177-191
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