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dc.contributor.author
Mondino, Alejandra
dc.contributor.author
González, Joaquín
dc.contributor.author
Li, Duan
dc.contributor.author
Mateos, Diego Martín
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dc.contributor.author
Osorio, Lucía
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dc.contributor.author
Cavelli, Matías
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Castro-Nin, Juan Pedro
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Serantes, Diego
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Costa, Alicia
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Vanini, Giancarlo
dc.contributor.author
Mashour, George A.
dc.contributor.author
Torterolo, Pablo
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dc.date.available
2023-02-10T11:09:00Z
dc.date.issued
2022-05
dc.identifier.citation
Mondino, Alejandra; González, Joaquín; Li, Duan; Mateos, Diego Martín; Osorio, Lucía; et al.; Urethane anaesthesia exhibits neurophysiological correlates of unconsciousness and is distinct from sleep; Wiley Blackwell Publishing, Inc; European Journal of Neuroscience; 5-2022; 1-19
dc.identifier.issn
0953-816X
dc.identifier.uri
http://hdl.handle.net/11336/187550
dc.description.abstract
Urethane is a general anaesthetic widely used in animal research. The state of urethane anaesthesia is unique because it alternates between macroscopically distinct electrographic states: a slow-wave state that resembles non-rapid eye movement (NREM) sleep and an activated state with features of both REM sleep and wakefulness. Although it is assumed that urethane produces unconsciousness, this has been questioned because of states of cortical activation during drug exposure. Furthermore, the similarities and differences between urethane anaesthesia and physiological sleep are still unclear. In this study, we recorded the electroencephalogram (EEG) and electromyogram in chronically prepared rats during natural sleep–wake states and during urethane anaesthesia. We subsequently analysed the power, coherence, directed connectivity and complexity of brain oscillations and found that EEG under urethane anaesthesia has clear signatures of unconsciousness, with similarities to other general anaesthetics. In addition, the EEG profile under urethane is different in comparison with natural sleep states. These results suggest that consciousness is disrupted during urethane. Furthermore, despite similarities that have led others to conclude that urethane is a model of sleep, the electrocortical traits of depressed and activated states during urethane anaesthesia differ from physiological sleep states.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANAESTHESIA
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CONSCIOUSNESS
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NREM
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REM
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SLEEP
dc.subject.classification
Otros Tópicos Biológicos
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dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Urethane anaesthesia exhibits neurophysiological correlates of unconsciousness and is distinct from sleep
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-02-08T15:36:47Z
dc.journal.pagination
1-19
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Mondino, Alejandra. Universidad de la República; Uruguay
dc.description.fil
Fil: González, Joaquín. Universidad de la República; Uruguay
dc.description.fil
Fil: Li, Duan. University of Michigan; Estados Unidos
dc.description.fil
Fil: Mateos, Diego Martín. Universidad Autónoma de Entre Ríos. Facultad de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
dc.description.fil
Fil: Osorio, Lucía. Universidad de la República; Uruguay
dc.description.fil
Fil: Cavelli, Matías. Universidad de la República; Uruguay
dc.description.fil
Fil: Castro-Nin, Juan Pedro. Universidad de la República; Uruguay
dc.description.fil
Fil: Serantes, Diego. Universidad de la República; Uruguay
dc.description.fil
Fil: Costa, Alicia. Universidad de la República; Uruguay
dc.description.fil
Fil: Vanini, Giancarlo. University of Michigan; Estados Unidos
dc.description.fil
Fil: Mashour, George A.. University of Michigan; Estados Unidos
dc.description.fil
Fil: Torterolo, Pablo. Universidad de la República; Uruguay
dc.journal.title
European Journal of Neuroscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/ejn.15690
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ejn.15690
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