Artículo
Urethane anaesthesia exhibits neurophysiological correlates of unconsciousness and is distinct from sleep
Mondino, Alejandra; González, Joaquín; Li, Duan; Mateos, Diego Martín
; Osorio, Lucía; Cavelli, Matías; Castro-Nin, Juan Pedro; Serantes, Diego; Costa, Alicia; Vanini, Giancarlo; Mashour, George A.; Torterolo, Pablo
Fecha de publicación:
05/2022
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
European Journal of Neuroscience
ISSN:
0953-816X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Urethane is a general anaesthetic widely used in animal research. The state of urethane anaesthesia is unique because it alternates between macroscopically distinct electrographic states: a slow-wave state that resembles non-rapid eye movement (NREM) sleep and an activated state with features of both REM sleep and wakefulness. Although it is assumed that urethane produces unconsciousness, this has been questioned because of states of cortical activation during drug exposure. Furthermore, the similarities and differences between urethane anaesthesia and physiological sleep are still unclear. In this study, we recorded the electroencephalogram (EEG) and electromyogram in chronically prepared rats during natural sleep–wake states and during urethane anaesthesia. We subsequently analysed the power, coherence, directed connectivity and complexity of brain oscillations and found that EEG under urethane anaesthesia has clear signatures of unconsciousness, with similarities to other general anaesthetics. In addition, the EEG profile under urethane is different in comparison with natural sleep states. These results suggest that consciousness is disrupted during urethane. Furthermore, despite similarities that have led others to conclude that urethane is a model of sleep, the electrocortical traits of depressed and activated states during urethane anaesthesia differ from physiological sleep states.
Palabras clave:
ANAESTHESIA
,
CONSCIOUSNESS
,
NREM
,
REM
,
SLEEP
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Identificadores
Colecciones
Articulos(IMAL)
Articulos de INST.DE MATEMATICA APLICADA "LITORAL"
Articulos de INST.DE MATEMATICA APLICADA "LITORAL"
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Mondino, Alejandra; González, Joaquín; Li, Duan; Mateos, Diego Martín; Osorio, Lucía; et al.; Urethane anaesthesia exhibits neurophysiological correlates of unconsciousness and is distinct from sleep; Wiley Blackwell Publishing, Inc; European Journal of Neuroscience; 5-2022; 1-19
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