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dc.contributor.author
Talevi, Alan
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dc.contributor.author
Bellera, Carolina Leticia
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dc.contributor.other
Talevi, Alan
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dc.date.available
2023-01-31T10:17:21Z
dc.date.issued
2021
dc.identifier.citation
Talevi, Alan; Bellera, Carolina Leticia; Real and apparent volumes of distribution; Springer Nature Switzerland AG; 1; 2021; 1-9
dc.identifier.isbn
978-3-030-51519-5
dc.identifier.uri
http://hdl.handle.net/11336/186205
dc.description.abstract
The real volume of distributionof a drug has physiological meaning, as it is related to the volume of body wateraccessible to the drug (including intracellular and extracellular fluid). Totalbody water represents 50%?70% of the total body weight; two thirds of itcorrespond to intracellular fluid, whereas the remaining one third correspondsto extracellular fluid (around 75% interstitial fluid and 25% plasma).Since an adult presents about 600 mL of body water per kilogram of bodyweight (which varies between 500 and 700 mL/kg depending on sex and age), the upper bound for the real volume ofdistribution of a drug will be around 42 L for a person weighing70 kg. No drug might have, for such an individual, a realvolume of distribution significantly above that approximate value. Furthermore,only a drug that can access all body volumes (plasma volume plus interstitialand intracellular fluids) would achieve the upper bound of the real volume ofdistribution. Conversely (i.e., if a drug does not fully distribute to a giventissue or organ), the real volume of distribution will be below thecorrespondent upper limit. After achieving systemic bioavailability, drugmolecules will almost instantaneously disperse within the plasma pool. Accordingly,the lower bound of the real volume of distribution would be the plasma volume,corresponding to a drug that can neither extravasate nor penetrate blood cells.Note that, as happens with other reference body volumes, plasma volume is alsosubject to significant variation across sex, age, body surface area, or diseasestates. For instance, male adults between 60 and 65 kg show plasma volumesclose to 3000 mL (mean plasma volume between 46.1 and 51.5 mL/kg,depending on the age group). The mean plasma volume per kilogram of body weighttends to be smaller in female adults, while a considerable plasma volumeexpansion (volume excess) has been observed in patients with chronic heartfailure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Nature Switzerland AG
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
APPARENT VOLUME OF DISTRIBUTION
dc.subject
REAL VOLUME OF DISTRIBUTION
dc.subject
STEADY STATE VOLUME OF DISTRIBUTION
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Real and apparent volumes of distribution
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-12-06T11:23:34Z
dc.journal.volume
1
dc.journal.pagination
1-9
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Basignstoke
dc.description.fil
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Bellera, Carolina Leticia. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1007/978-3-030-51519-5_52-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/referenceworkentry/10.1007/978-3-030-51519-5_52-1
dc.conicet.paginas
1500
dc.source.titulo
The ADME encyclopedia: A comprehensive guide on biopharmacy and pharmacokinetics
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