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dc.contributor.author
Talevi, Alan
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dc.contributor.author
Bellera, Carolina Leticia
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dc.contributor.other
Talevi, Alan
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dc.date.available
2023-01-30T14:13:44Z
dc.date.issued
2021
dc.identifier.citation
Talevi, Alan; Bellera, Carolina Leticia; Organic anion transporters and organic anion transporting polypeptides; Springer Nature Switzerland AG; 2021; 1-7
dc.identifier.isbn
978-3-030-51519-5
dc.identifier.uri
http://hdl.handle.net/11336/186097
dc.description.abstract
Organic anion transporters (OATs) are members of the solutecarrier (SLC) group of transporters and belong to the Major Facilitatorsuperfamily (MFS). According to the Human Genome Organization (HUGO), they areassigned to the SLC22A family, that also includes the Organic CationTransporters (OCTs) and the Organic Carnitine (zwitterion) Transporters (alsoknown as Novel Organic Cation Transporters, OCTNs), with which OATs share manygeneral structural features. OATs are multispecific carriers that transportrather small organic anions, including endogenous compounds, such asp-aminohippurate, prostaglandins, guanine nucleotide-related compounds, cGMP,and steroid conjugates, among others, and also exogenous compounds includingmany antivirals, nonsteroidal anti-inflammatory drugs, statins, diureticagents, antimetabolites, and antibiotics, among others. They have a pivotalrole in the basolateral (Phase 0) uptake of their substrates into epithelialcells of drug-eliminating organs and also in drug reabsorption. In humans, mostOATs are highly expressed in the human liver and kidneys, and at lower levels inthe brain, placenta, testis, and prostate. OATs from the SLC22A family includeOAT1-10 (SLC22A6, SLC22A7, SLC22A8, SLC22A11, SLC22A10, SLC22A20, SLC22A9,SLC22A25, SLC22A27, SLC22A13, in that order) and the urate transporter URAT1(SLC22A12). Whereas prototypical members of the SLC22A family can mediate thebidirectional movement of substrates, most of the OATs generally facilitate theuptake of organic anions into epithelial cells (functioning as influxtransporters) by secondary/tertiary active transport (specifically, by exchangewith dicarboxylates, such as α-ketoglutarate) or monocarboxylates.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Nature Switzerland AG
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DRUG TRANSPORT
dc.subject
DRUG TRANSPORTERS
dc.subject
DRUG CARRIERS
dc.subject
PHASE 0 TRANSPORT
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Organic anion transporters and organic anion transporting polypeptides
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-12-06T11:21:27Z
dc.journal.pagination
1-7
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Basignstoke
dc.description.fil
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Bellera, Carolina Leticia. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1007/978-3-030-51519-5_84-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/referenceworkentry/10.1007/978-3-030-51519-5_84-1
dc.conicet.paginas
1500
dc.source.titulo
The ADME encyclopedia. A comprehensive guide on biopharmacy and pharmacokinetics
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