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dc.contributor.author
van Emden, Thomas S.
dc.contributor.author
Forn, Marta
dc.contributor.author
Forné, Ignasi
dc.contributor.author
Sarkadi, Zsuzsa
dc.contributor.author
Capella, Matias
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dc.contributor.author
Martín Caballero, Lucía
dc.contributor.author
Fischer Burkart, Sabine
dc.contributor.author
Brönner, Cornelia
dc.contributor.author
Simonetta, Marco
dc.contributor.author
Toczyski, David
dc.contributor.author
Halic, Mario
dc.contributor.author
Imhof, Axel
dc.contributor.author
Braun, Sigurd
dc.date.available
2023-01-23T15:10:01Z
dc.date.issued
2019-01
dc.identifier.citation
van Emden, Thomas S.; Forn, Marta; Forné, Ignasi; Sarkadi, Zsuzsa; Capella, Matias; et al.; Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability; Nature Publishing Group; Embo Reports; 20; 1; 1-2019; 1-17
dc.identifier.issn
1469-221X
dc.identifier.uri
http://hdl.handle.net/11336/185278
dc.description.abstract
Telomeres and the shelterin complex cap and protect the ends of chromosomes. Telomeres are flanked by the subtelomeric sequences that have also been implicated in telomere regulation, although their role is not well defined. Here, we show that, in Schizosaccharomyces pombe, the telomere-associated sequences (TAS) present on most subtelomeres are hyper-recombinogenic, have metastable nucleosomes, and unusual low levels of H3K9 methylation. Ccq1, a subunit of shelterin, protects TAS from nucleosome loss by recruiting the heterochromatic repressor complexes CLRC and SHREC, thereby linking nucleosome stability to gene silencing. Nucleosome instability at TAS is independent of telomeric repeats and can be transmitted to an intrachromosomal locus containing an ectopic TAS fragment, indicating that this is an intrinsic property of the underlying DNA sequence. When telomerase recruitment is compromised in cells lacking Ccq1, DNA sequences present in the TAS promote recombination between chromosomal ends, independent of nucleosome abundance, implying an active function of these sequences in telomere maintenance. We propose that Ccq1 and fragile subtelomeres co-evolved to regulate telomere plasticity by controlling nucleosome occupancy and genome stability.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GENOME STABILITY
dc.subject
HETEROCHROMATIN
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NUCLEOSOMES
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SHELTERIN
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TELOMERES
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-01-23T00:35:12Z
dc.journal.volume
20
dc.journal.number
1
dc.journal.pagination
1-17
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: van Emden, Thomas S.. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Forn, Marta. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Forné, Ignasi. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Sarkadi, Zsuzsa. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Capella, Matias. Ludwig Maximilians Universitat; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Martín Caballero, Lucía. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Fischer Burkart, Sabine. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Brönner, Cornelia. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Simonetta, Marco. University of California; Estados Unidos
dc.description.fil
Fil: Toczyski, David. University of California; Estados Unidos
dc.description.fil
Fil: Halic, Mario. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Imhof, Axel. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Braun, Sigurd. Ludwig Maximilians Universitat; Alemania
dc.journal.title
Embo Reports
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.15252/embr.201847181
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