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dc.contributor.author
Talevi, Alan
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dc.contributor.author
Bellera, Carolina Leticia
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dc.contributor.other
Talevi, Alan
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dc.date.available
2023-01-19T10:47:06Z
dc.date.issued
2021
dc.identifier.citation
Talevi, Alan; Bellera, Carolina Leticia; Two-Compartment Pharmacokinetic Model; Springer Nature Switzerland AG; 2021; 1-8
dc.identifier.isbn
978-3-030-51519-5
dc.identifier.uri
http://hdl.handle.net/11336/184965
dc.description.abstract
The two-compartment pharmacokinetic model describes the evolution of drug levels in the organism by depicting the body as two pharmacokinetic compartments (the central and the peripheral compartments, also commonly referred to as compartment 1 and compartment 2, in that order). Once a given drug amount reaches one of these compartments, it distributes throughout it immediately and homogenously. However, movement from one compartment to the other is not instantaneous but follows first-order kinetics. As in the onecompartment model, drug elimination occurs following (apparent) first-order kinetics. By default (i.e., unless otherwise specified), it is assumed that elimination occurs only from the central compartment. Depending on the modelled therapeutic scenario, drug absorption will be assumed to be instantaneous (e.g., intravenous bolus) or to follow zero- or first-order kinetics (e.g., constantrate intravenous infusion or extravascular drug administration, respectively). It is also assumed that the drug initially enters the central compartment, from which it distributes to the peripheral one. Two-compartment models are the most common in population pharmacokinetic modeling: it has been estimated that they represent around 80% of published models. By integrating the mass balances for each compartment, it is possible to obtain equations of drug amount in each compartment versus time.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Nature Switzerland AG
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COMPARTMENTAL MODELS
dc.subject
PLASMA CONCENTRATION-TIME CURVE
dc.subject
DRUG DISTRIBUTION
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Two-Compartment Pharmacokinetic Model
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-12-06T11:23:19Z
dc.journal.pagination
1-8
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Basignstoke
dc.description.fil
Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina
dc.description.fil
Fil: Bellera, Carolina Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/referenceworkentry/10.1007/978-3-030-51519-5_59-1
dc.conicet.paginas
1500
dc.source.titulo
The ADME Encyclopedia: A Comprehensive Guide on Biopharmacy and Pharmacokinetics
dc.conicet.nroedicion
1
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