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dc.contributor.author
Glisoni, Romina Julieta
dc.contributor.author
Castro, Eliana Florencia
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Cavallaro, Lucia Vicenta
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Moglioni, Albertina Gladys
dc.contributor.author
Sosnik, Alejandro Dario
dc.date.available
2017-06-19T17:36:28Z
dc.date.issued
2015-02
dc.identifier.citation
Glisoni, Romina Julieta; Castro, Eliana Florencia; Cavallaro, Lucia Vicenta; Moglioni, Albertina Gladys; Sosnik, Alejandro Dario; Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 15; 6; 2-2015; 4224-4228
dc.identifier.issn
1533-4880
dc.identifier.uri
http://hdl.handle.net/11336/18429
dc.description.abstract
The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-β-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model. Results showed a potent suppression of the virus replication, with greater activity for the inclusion complexes than the free compound.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Scientific Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bovine Viral Diarrhea Virus (Bvdv)
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Hydroxypropyl-B-Cyclodextrin Inclusion Complexes
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1-Indanone Thiosemicarbazones
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Hcv Surrogate Model
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Hydroxypropyl-Β-Cyclodextrin Inclusion Complexes
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Direct-Acting Antiviral Agents
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Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-16T21:31:53Z
dc.journal.volume
15
dc.journal.number
6
dc.journal.pagination
4224-4228
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Valencia
dc.description.fil
Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Castro, Eliana Florencia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cavallaro, Lucia Vicenta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Technion - Israel Institute of Technology; Israel
dc.journal.title
Journal of Nanoscience and Nanotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/jnn/2015/00000015/00000006/art00027
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1166/jnn.2014.9613


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