Artículo
Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
Glisoni, Romina Julieta
; Castro, Eliana Florencia
; Cavallaro, Lucia Vicenta; Moglioni, Albertina Gladys
; Sosnik, Alejandro Dario
![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
02/2015
Editorial:
American Scientific Publishers
Revista:
Journal of Nanoscience and Nanotechnology
ISSN:
1533-4880
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-β-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model. Results showed a potent suppression of the virus replication, with greater activity for the inclusion complexes than the free compound.
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Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Glisoni, Romina Julieta; Castro, Eliana Florencia; Cavallaro, Lucia Vicenta; Moglioni, Albertina Gladys; Sosnik, Alejandro Dario; Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 15; 6; 2-2015; 4224-4228
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