Mostrar el registro sencillo del ítem
dc.contributor.author
Merkier, Andrea Karina
dc.contributor.author
Rodríguez, María Cecilia
dc.contributor.author
Togneri, Ana
dc.contributor.author
Brengio, Silvia Diana
dc.contributor.author
Osuna, Carolina
dc.contributor.author
Pichel, Mariana
dc.contributor.author
Cassini, Marcelo Hernan
dc.contributor.author
Centron, Daniela
dc.contributor.author
Serratia marcescens Argentinean Collaborative Group
dc.date.available
2015-08-26T17:30:31Z
dc.date.issued
2013-07
dc.identifier.citation
Merkier, Andrea Karina; Rodríguez, María Cecilia; Togneri, Ana; Brengio, Silvia Diana; Osuna, Carolina; et al.; Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting; American Society for Microbiology; Journal of Clinical Microbiology; 51; 7; 7-2013; 2295-2302
dc.identifier.issn
0095-1137
dc.identifier.uri
http://hdl.handle.net/11336/1827
dc.description.abstract
Serratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n = 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::blaCTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Serratia Marcescens
dc.subject
Outbreak
dc.subject
Colistin
dc.subject
Integrons
dc.subject.classification
Epidemiología
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1098-660X
dc.journal.volume
51
dc.journal.number
7
dc.journal.pagination
2295-2302
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Merkier, Andrea Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Rodríguez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Togneri, Ana. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; Argentina
dc.description.fil
Fil: Brengio, Silvia Diana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Mendoza. Instituto Argentino de Investigaciones de Zonas Aridas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Osuna, Carolina. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología; Argentina
dc.description.fil
Fil: Pichel, Mariana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Cassini, Marcelo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas. Grupo de Estudios en Ecología de Mamíferos; Argentina
dc.description.fil
Fil: Centron, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Serratia marcescens Argentinean Collaborative Group. No especifíca;
dc.journal.title
Journal of Clinical Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697717/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1128/JCM.03280-12
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jcm.asm.org/content/51/7/2295.full.pdf+html
Archivos asociados