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Artículo

Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting

Merkier, Andrea Karina; Rodríguez, María Cecilia; Togneri, Ana; Brengio, Silvia DianaIcon ; Osuna, Carolina; Pichel, Mariana; Cassini, Marcelo HernanIcon ; Centron, DanielaIcon ; Serratia marcescens Argentinean Collaborative Group
Fecha de publicación: 07/2013
Editorial: American Society for Microbiology
Revista: Journal of Clinical Microbiology
ISSN: 0095-1137
e-ISSN: 1098-660X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Epidemiología; Biología Celular, Microbiología

Resumen

Serratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n = 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::blaCTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.
Palabras clave: Serratia Marcescens , Outbreak , Colistin , Integrons
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/1827
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697717/
DOI: http://dx.doi.org/doi:10.1128/JCM.03280-12
URL: http://jcm.asm.org/content/51/7/2295.full.pdf+html
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Merkier, Andrea Karina; Rodríguez, María Cecilia; Togneri, Ana; Brengio, Silvia Diana; Osuna, Carolina; et al.; Outbreak of a Cluster with Epidemic Behavior due to Serratia marcescens after colistin administration in a hospital setting; American Society for Microbiology; Journal of Clinical Microbiology; 51; 7; 7-2013; 2295-2302
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