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dc.contributor.author
Apostolopoulos, Vasso  
dc.contributor.author
Bojarska, Joanna  
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Chai, Tsun Thai  
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Elnagdy, Sherif  
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Kaczmarek, Krzysztof  
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Matsoukas, John  
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New, Roger  
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Parang, Keykavous  
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Paredes Lopez, Octavio  
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Parhiz, Hamideh  
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Perera, Conrad O.  
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Pickholz, Mónica Andrea  
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Remko, Milan  
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Saviano, Michele  
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Skwarczynski, Mariusz  
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Tang, Yefeng  
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Wolf, Wojciech M.  
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Yoshiya, Taku  
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Zabrocki, Janusz  
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Zielenkiewicz, Piotr  
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AlKhazindar, Maha  
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Barriga, Vanessa  
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Kelaidonis, Konstantinos  
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Sarasia, Elham Mousavinezhad  
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Toth, Istvan  
dc.date.available
2022-12-22T17:27:44Z  
dc.date.issued
2021-01  
dc.identifier.citation
Apostolopoulos, Vasso; Bojarska, Joanna; Chai, Tsun Thai; Elnagdy, Sherif; Kaczmarek, Krzysztof; et al.; A global review on short peptides: Frontiers and perspectives; Molecular Diversity Preservation International; Molecules; 26; 2; 1-2021; 1-45  
dc.identifier.issn
1420-3049  
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http://hdl.handle.net/11336/182235  
dc.description.abstract
Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Molecular Diversity Preservation International  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ALTERED PEPTIDE LIGANDS  
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ANT/SUPER/AGONISTS  
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APTAMERS  
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BILAYER INTERACTIONS  
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CANCER  
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CELL-PENETRATING PEPTIDES  
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CONSTRAINED AMINO ACIDS AND PEPTIDE (BIO)MIMETICS  
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COSMECEUTICALS  
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DIKETOPIPERAZINE  
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DRUG DESIGN AND DRUG/GENE DELIVERY  
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SARS-COV-2  
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SHORT PEPTIDES  
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SYNTHESIS  
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VACCINES  
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Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
A global review on short peptides: Frontiers and perspectives  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-09-28T13:41:14Z  
dc.journal.volume
26  
dc.journal.number
2  
dc.journal.pagination
1-45  
dc.journal.pais
Suiza  
dc.journal.ciudad
Basilea  
dc.description.fil
Fil: Apostolopoulos, Vasso. Victoria University; Alemania  
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Fil: Bojarska, Joanna. Lodz University of Technology; Polonia  
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Fil: Chai, Tsun Thai. Universiti Tunku Abdul Rahman; Malasia  
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Fil: Elnagdy, Sherif. Cairo University; Egipto  
dc.description.fil
Fil: Kaczmarek, Krzysztof. Lodz University of Technology; Polonia  
dc.description.fil
Fil: Matsoukas, John. Patras Science Park; Canadá. Victoria University; Australia. University of Calgary; Canadá  
dc.description.fil
Fil: New, Roger. Middlesex University; Reino Unido. London Bioscience Innovation Centre; Reino Unido  
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Fil: Parang, Keykavous. Chapman University; Estados Unidos  
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Fil: Paredes Lopez, Octavio. Centro de Investigacion y de Estudio Avanzados, Campus Guanajuato; México  
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Fil: Parhiz, Hamideh. University of Pennsylvania; Estados Unidos  
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Fil: Perera, Conrad O.. University of Auckland; Nueva Zelanda  
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Fil: Pickholz, Mónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina  
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Fil: Remko, Milan. Remedika; Eslovaquia  
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Fil: Saviano, Michele. Consiglio Nazionale delle Ricerche; Italia  
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Fil: Skwarczynski, Mariusz. University of Queensland; Australia. The University of Queensland; Australia  
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Fil: Tang, Yefeng. Tsinghua University; China  
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Fil: Wolf, Wojciech M.. Lodz University of Technology; Polonia  
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Fil: Yoshiya, Taku. Peptide Institute; Japón  
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Fil: Zabrocki, Janusz. Lodz University of Technology; Polonia  
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Fil: Zielenkiewicz, Piotr. Uniwersytet Warszawski; Argentina. Polish Academy of Sciences; Argentina  
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Fil: AlKhazindar, Maha. Cairo University; Egipto  
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Fil: Barriga, Vanessa. Victoria University; Australia  
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Fil: Kelaidonis, Konstantinos. Patras Science Park; Grecia  
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Fil: Sarasia, Elham Mousavinezhad. Middlesex University; Reino Unido  
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Fil: Toth, Istvan. University of Queensland; Australia. The University of Queensland; Australia  
dc.journal.title
Molecules  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/molecules26020430  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/2/430