Mostrar el registro sencillo del ítem
dc.contributor.author
Ricatti, Maria Jimena
dc.contributor.author
Battista, Ariadna Gabriela
dc.contributor.author
Zorrilla Zubilete, María Aurelia
dc.contributor.author
Faillace, Maria Paula
dc.date.available
2017-06-14T21:31:45Z
dc.date.issued
2011-04
dc.identifier.citation
Ricatti, Maria Jimena; Battista, Ariadna Gabriela; Zorrilla Zubilete, María Aurelia; Faillace, Maria Paula; Purinergic signals regulate daily s-phase cell activity in the ciliary marginal zone of the zebrafish retina; SAGE Publications; Journal of Biological Rhythms; 26; 2; 4-2011; 107-117
dc.identifier.issn
0748-7304
dc.identifier.uri
http://hdl.handle.net/11336/18222
dc.description.abstract
Regeneration and growth that occur in the adult teleost retina have been helpful in identifying molecular and cellular mechanisms underlying cell proliferation and differentiation. Here, it is reported that S-phase cell number, in the ciliary marginal zone (CMZ) of the adult zebrafish retina, exhibits day-night variations with a mid-light phase peak. Oscillations persist for 24 h in constant darkness (DD), suggesting control by a circadian component. However, variations in the S-phase nuclei number were rapidly dampened and not present during and after a second day in DD. An ADPβS treatment significantly enhanced S-phase activity at night to mid-light levels, as assessed by in vivo BrdU incorporation in a 2-h interval. Moreover, daylight increase in S-phase cell number was completely abolished when extracellular nucleotide levels or their extracellular hydrolysis by ectonucleoside triphosphate diphosphohydrolases (NTPDases) were significantly disrupted or when a selective antagonist of purinergic P2Y1 receptors was intraocularly injected before BrdU exposure. Extracellular nucleotides and NTPDase action were also important for maintaining nocturnal low levels of S-phase activity in the CMZ. Finally, we showed that mRNAs of NTPDases 1, 2 (3 isoforms), and 3 as well as of P2Y1 receptor are present in the neural retina of zebrafish. NTPDase mRNA expression exhibited a 2-fold increment in light versus dark conditions as assessed by quantitative RT-PCR, whereas P2Y1 receptor mRNA levels did not show significant day-night variations. This study demonstrates a key role for nucleotides, principally ADP as a paracrine signal, as well as for NTPDases, the plasma membrane—bound enzymes that control extracellular nucleotide concentration, for inducing S-phase cell entry in the CMZ—normally associated with retinal growth—throughout the light-dark cycle.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CILIARY MARGINAL ZONE
dc.subject
EXTRACELLULAR NUCLEOTIDES
dc.subject
S-PHASE CELL RHYTHM
dc.subject
ZEBRAFISH RETINA
dc.subject.classification
Biología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Purinergic signals regulate daily s-phase cell activity in the ciliary marginal zone of the zebrafish retina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-14T14:34:25Z
dc.identifier.eissn
1552-4531
dc.journal.volume
26
dc.journal.number
2
dc.journal.pagination
107-117
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Thousand Oaks
dc.description.fil
Fil: Ricatti, Maria Jimena. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Battista, Ariadna Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Zorrilla Zubilete, María Aurelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Faillace, Maria Paula. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
dc.journal.title
Journal of Biological Rhythms
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/abs/10.1177/0748730410395528
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0748730410395528
Archivos asociados