Artículo
Programmed cell death in the small intestine: Implications for the pathogenesis of celiac disease
Perez, Federico
; Ruera, Carolina Naymé
; Miculán, Emanuel Gonzalo
; Carasi, Paula
; Chirdo, Fernando Gabriel
Fecha de publicación:
07/2021
Editorial:
Molecular Diversity Preservation International
Revista:
International Journal of Molecular Sciences
ISSN:
1422-0067
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The small intestine has a high rate of cell turnover under homeostatic conditions, and this increases further in response to infection or damage. Epithelial cells mostly die by apoptosis, but recent studies indicate that this may also involve pro-inflammatory pathways of programmed cell death, such as pyroptosis and necroptosis. Celiac disease (CD), the most prevalent immune-based enteropathy, is caused by loss of oral tolerance to peptides derived from wheat, rye, and barley in genetically predisposed individuals. Although cytotoxic cells and gluten-specific CD4+ Th1 cells are the central players in the pathology, inflammatory pathways induced by cell death may participate in driving and sustaining the disease through the release of alarmins. In this review, we summarize the recent literature addressing the role of programmed cell death pathways in the small intestine, describing how these mechanisms may contribute to CD and discussing their potential implications.
Palabras clave:
ALARMINS
,
CELIAC DISEASE
,
INFLAMMATION
,
PROGRAMMED CELL DEATH
,
SMALL INTESTINE
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Articulos(IIFP)
Articulos de INST. DE ESTUDIOS INMUNOLOGICOS Y FISIOPATOLOGICOS
Articulos de INST. DE ESTUDIOS INMUNOLOGICOS Y FISIOPATOLOGICOS
Citación
Perez, Federico; Ruera, Carolina Naymé; Miculán, Emanuel Gonzalo; Carasi, Paula; Chirdo, Fernando Gabriel; Programmed cell death in the small intestine: Implications for the pathogenesis of celiac disease; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 22; 14; 7-2021; 1-21
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