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dc.contributor.author
Gold, Marielle C.
dc.contributor.author
McLaren, James E.
dc.contributor.author
Reistetter, Joseph A.
dc.contributor.author
Smyk Pearson, Sue
dc.contributor.author
Ladell, Kristin
dc.contributor.author
Swarbrick, Gwendolyn M.
dc.contributor.author
Yu, Yik Y. L.
dc.contributor.author
Hansen, Ted H.
dc.contributor.author
Lund, Ole
dc.contributor.author
Nielsen, Morten
dc.contributor.author
Gerritsen, Bram
dc.contributor.author
Kesmir, Can
dc.contributor.author
Miles, John J.
dc.contributor.author
Lewinsohn, Deborah A.
dc.contributor.author
Price, David A.
dc.contributor.author
Lewinsohn, David M.
dc.date.available
2017-06-13T16:52:11Z
dc.date.issued
2014-07
dc.identifier.citation
Gold, Marielle C.; McLaren, James E.; Reistetter, Joseph A.; Smyk Pearson, Sue; Ladell, Kristin; et al.; MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage; Rockefeller Univ Press; Journal Of Experimental Medicine; 211; 8; 7-2014; 1601-1610
dc.identifier.issn
0022-1007
dc.identifier.uri
http://hdl.handle.net/11336/18089
dc.description.abstract
Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that detects microbial metabolites presented by the nonpolymorphic major histocompatibility complex (MHC)–like molecule MR1. The highly conserved nature of MR1 in conjunction with biased MAIT TCRα chain usage is widely thought to indicate limited ligand presentation and discrimination within a pattern-like recognition system. Here, we evaluated the TCR repertoire of MAIT cells responsive to three classes of microbes. Substantial diversity and heterogeneity were apparent across the functional MAIT cell repertoire as a whole, especially for TCRβ chain sequences. Moreover, different pathogen-specific responses were characterized by distinct TCR usage, both between and within individuals, suggesting that MAIT cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes. In line with this interpretation, MAIT cell clones with distinct TCRs responded differentially to a riboflavin metabolite. These results suggest that MAIT cells can discriminate between pathogen-derived ligands in a clonotype-dependent manner, providing a basis for adaptive memory via recruitment of specific repertoires shaped by microbial exposure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Rockefeller Univ Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mait
dc.subject
T Cell
dc.subject
T Cell Receptor
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-09T15:01:04Z
dc.journal.volume
211
dc.journal.number
8
dc.journal.pagination
1601-1610
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Birmingham
dc.description.fil
Fil: Gold, Marielle C.. Oregon Health & Science University; Estados Unidos
dc.description.fil
Fil: McLaren, James E.. Cardiff University; Reino Unido
dc.description.fil
Fil: Reistetter, Joseph A.. Oregon Health & Science University; Estados Unidos
dc.description.fil
Fil: Smyk Pearson, Sue. Oregon Health & Science University; Estados Unidos
dc.description.fil
Fil: Ladell, Kristin. Cardiff University; Reino Unido
dc.description.fil
Fil: Swarbrick, Gwendolyn M.. Oregon Health & Science University; Estados Unidos
dc.description.fil
Fil: Yu, Yik Y. L.. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Hansen, Ted H.. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Lund, Ole. Technical University of Denmark; Dinamarca
dc.description.fil
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.fil
Fil: Gerritsen, Bram. Utrecht Univeristy; Países Bajos
dc.description.fil
Fil: Kesmir, Can. Utrecht Univeristy; Países Bajos
dc.description.fil
Fil: Miles, John J.. Cardiff University; Reino Unido
dc.description.fil
Fil: Lewinsohn, Deborah A.. Oregon Health & Science University; Estados Unidos
dc.description.fil
Fil: Price, David A.. Cardiff University; Reino Unido. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Lewinsohn, David M.. Oregon Health & Science University; Estados Unidos
dc.journal.title
Journal Of Experimental Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jem.rupress.org/content/211/8/1601.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1084/jem.20140507
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113934/
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