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dc.contributor.author
Miles, Sebastián
dc.contributor.author
Magnone, Javier
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García Luna, Joaquín
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Ancarola, María Eugenia
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Cucher, Marcela Alejandra
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Dematteis, Sylvia
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Frischknecht, Friedrich
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Cyrklaff, Marek
dc.contributor.author
Mourglia Ettlin, Gustavo
dc.date.available
2022-11-15T13:42:34Z
dc.date.issued
2021-11
dc.identifier.citation
Miles, Sebastián; Magnone, Javier; García Luna, Joaquín; Ancarola, María Eugenia; Cucher, Marcela Alejandra; et al.; Ultrastructural characterization of the tegument in protoscoleces of Echinococcus ortleppi; Elsevier; International Journal for Parasitology; 51; 12; 11-2021; 989-997
dc.identifier.issn
0020-7519
dc.identifier.uri
http://hdl.handle.net/11336/177818
dc.description.abstract
Cystic echinococcosis is a globally distributed zoonosis caused by cestodes of the Echinococcus granulosus sensu lato (s.l.) complex, with Echinococcus ortleppi mainly involved in cattle infection. Protoscoleces show high developmental plasticity, being able to differentiate into either adult worms or metacestodes within definitive or intermediate hosts, respectively. Their outermost cellular layer is called the tegument, which is important in determining the infection outcome through its immunomodulating activities. Herein, we report an in-depth characterization of the tegument of E. ortleppi protoscoleces performed through a combination of scanning and transmission electron microscopy techniques. Using electron tomography, a three-dimensional reconstruction of the tegumental cellular territories was obtained, revealing a novel structure termed the ‘tegumental vesicular body’ (TVB). Vesicle-like structures, possibly involved in endocytic/exocytic routes, were found within the TVB as well as in the parasite glycocalyx, distal cytoplasm and close inner structures. Furthermore, parasite antigens (GST-1 and AgB) were unevenly localised within tegumental structures, with both being detected in vesicles found within the TBV. Finally, the presence of host (bovine) IgG was also assessed, suggesting a possible endocytic route in protoscoleces. Our data forms the basis for a better understanding of E. ortleppi and E. granulosus s.l. structural biology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ECHINOCOCCUS GRANULOSUS
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ECHINOCOCCUS ORTLEPPI
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ELECTRON MICROSCOPY
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ELECTRON TOMOGRAPHY
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PROTOSCOLEX
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STRUCTURAL BIOLOGY
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TEGUMENT
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VESICLES
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Ultrastructural characterization of the tegument in protoscoleces of Echinococcus ortleppi
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T14:14:32Z
dc.journal.volume
51
dc.journal.number
12
dc.journal.pagination
989-997
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Miles, Sebastián. Universidad de la República. Facultad de Ciencias; Uruguay
dc.description.fil
Fil: Magnone, Javier. Universidad de la República. Facultad de Ciencias; Uruguay
dc.description.fil
Fil: García Luna, Joaquín. Universidad de la República. Facultad de Ciencias; Uruguay
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Fil: Ancarola, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Cucher, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Dematteis, Sylvia. Universidad de la República. Facultad de Ciencias; Uruguay. Universidad de la República. Facultad de Química; Uruguay
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Fil: Frischknecht, Friedrich. Heidelberg University; Alemania
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Fil: Cyrklaff, Marek. Heidelberg University; Alemania
dc.description.fil
Fil: Mourglia Ettlin, Gustavo. Universidad de la República. Facultad de Ciencias; Uruguay. Universidad de la República. Facultad de Química; Uruguay
dc.journal.title
International Journal for Parasitology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0020751921002125
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijpara.2021.05.004
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