Artículo
Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma
Bessone, Carolina del Valle
; Akhlaghi, Seyedeh Parinaz; Tartara, Luis Ignacio
; Quinteros, Daniela Alejandra
; Loh, Watson; Allemandi, Daniel Alberto
Fecha de publicación:
05/2021
Editorial:
Elsevier Science
Revista:
European Journal of Pharmaceutical Sciences
ISSN:
0928-0987
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Glaucoma is a degenerative optic neuropathy characterized by increased intraocular pressure that if untreated can result in blindness. Ophthalmological drug therapy is a challenge of great clinical importance due to the diversity of ocular biological barriers which commonly causes limited or no effectiveness for drugs delivered through the eye. In this work, we proposed the development of nanosized cubic liquid crystals (cubosomes) as a new drug carrier system for latanoprost, an anti-glaucoma drug. Latanoprost-loaded phytantriol cubosomes (CubLnp) were prepared using a top-down method. Latanoprost concentration in the formulations ranged from 0.00125% to 0.02% w/v. All cubosomes displayed an average size around 200 nm, a low polydispersity index of 0.1 and zeta potential values around ?25 mV, with an encapsulation efficiency of about 90%. Structural studies revealed that cubosomes displayed a double-diamond surface, Pn3m cubic-phase structure, and was not affected by drug loading. Calorimetric studies revealed a fast and exothermic interaction between latanoprost and cubosomes. According to in vitro essays, latanoprost release from cubosomes was slow in time, evidencing a sustained release profile. Based on this behavior, the in vivo hypotensive intraocular effect was evaluated by means of the subconjunctival administration of CubLnp in normotensive rabbits. We obtained promising results in comparison with a marketed latanoprost formulation (0.005% w/v).
Palabras clave:
CUBOSOMES
,
GLAUCOMA
,
IN VIVO ESSAYS
,
LATANOPROST
,
NANOPARTICLES
,
PHYTANTRIOL
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Colecciones
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Bessone, Carolina del Valle; Akhlaghi, Seyedeh Parinaz; Tartara, Luis Ignacio; Quinteros, Daniela Alejandra; Loh, Watson; et al.; Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma; Elsevier Science; European Journal of Pharmaceutical Sciences; 160; 105748; 5-2021; 1-11
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