Capítulo de Libro
Antiproliferative and Cytotoxic Activities
Título del libro: Sesquiterpene lactones: Advances in their Chemistry and Biological Aspects
Fecha de publicación:
2018
Editorial:
Springer
ISBN:
978-3-319-78273-7
Idioma:
Inglés
Clasificación temática:
Resumen
Cancer is a genetic disease, affecting many people worldwide.Chemotherapy is routinely used for cancer treatment. However, this therapeuticapproach is not always effective due to the development of cell resistance and toxiceffects. Plants are a reservoir of natural chemicals with chemoprotective potentialagainst cancer and with low adverse effects. While some drugs from natural originare currently used for cancer treatment, others are being studied. Among the compoundsisolated from plants, sesquiterpene lactones are very promising anticanceragents, which are widely being studied in different models of cancer in vitro andin vivo, and some clinical trials are being performed. Sesquiterpene lactones arevery attractive compounds to be used as antitumoral therapy due to the diversemechanisms of action through which they exert their effects. Among suchmechanismsare their capacity to interfere with the generation of reactive oxygenspecies, the epigenetic modulation of gene expression, the targeting of the sarco-/endoplasmic reticulum calcium ATPase pump, and the activation of the NF-kB andthe p53 signaling pathways. The latter mechanisms could be important to reduce thedevelopment of drug resistance by tumor cells. Sesquiterpene lactones can alsoinhibit angiogenesis and metastasis.
Palabras clave:
SESQUITERPEN LACTONES
,
CANCER
,
CYTOTOXICITY
Archivos asociados
Licencia
Identificadores
Colecciones
Capítulos de libros(IQUIMEFA)
Capítulos de libros de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Capítulos de libros de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Anesini, Claudia Alejandra; Alonso, Maria del Rosario; Martino, Renzo Fabricio; Antiproliferative and Cytotoxic Activities; Springer; 2018; 1-500
Compartir
Items relacionados
Mostrando titulos relacionados por título, autor y tema.
-
Capítulo de Libro Biosynthesis in plants and metabolic engineering for their biotechnological productionTítulo del libro: Sesquiterpene lactones: Advances in their chemistry and biological aspectsPerassolo, Maria ; Cardillo, Sabrina Beatriz ; Busto, Víctor Daniel ; Giulietti, Ana Maria ; Rodriguez Talou, Julian - Otros responsables: Sülsen, Valeria Patricia Martino, Virginia Susana - (Springer Verlag Berlín, 2018)
-
Capítulo de Libro Spectroscopic methods for the identification of sesquiterpene lactonesTítulo del libro: Sesquiterpene lactones: Advances in their chemistry and biological aspectsSülsen, Valeria Patricia ; Donadel, Osvaldo Juan; Catalan, Cesar Atilio Nazareno - Otros responsables: Sülsen, Valeria Patricia Martino, Virginia Susana - (Springer, 2018)
-
Capítulo de Libro Anti-inflammatory ActivityTítulo del libro: Sesquiterpene lactones: Advances in their Chemistry and Biological AspectsAlonso, Maria del Rosario ; Anesini, Claudia Alejandra ; Martino, Renzo Fabricio - Otros responsables: Sülsen, Valeria Patricia Martino, Virginia Susana - (Springer, 2018)
-
Capítulo de Libro OverviewTítulo del libro: Sesquiterpene lactones: Advances in their chemistry and biological aspectsSülsen, Valeria Patricia ; Martino, Virginia Susana - Otros responsables: Sülsen, Valeria Patricia Martino, Virginia Susana - (Springer, 2018)
-
Capítulo de Libro Analytical proceduresTítulo del libro: Sesquiterpene lactones: Advances in their chemistry and biological aspectsSülsen, Valeria Patricia ; Catalan, Cesar Atilio Nazareno ; Martino, Virginia Susana - Otros responsables: Sülsen, Valeria Patricia Martino, Virginia Susana - (Springer, 2018)
-
Capítulo de Libro Mode of action on Trypanosoma ad Leishmania sppTítulo del libro: Sesquiterpene Lactones: Advances in their Chemistry and Biological AspectsLombardo, Maria Elisa ; Batlle, Alcira Maria del C. - Otros responsables: Sülsen, Valeria Patricia Martino, Virginia Susana - (Springer, 2018)