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dc.contributor.author
Morales Polanco, Fabian
dc.contributor.author
Bates, Christian
dc.contributor.author
Lui, Jennifer
dc.contributor.author
Casson, Joseph
dc.contributor.author
Solari, Clara Andrea
dc.contributor.author
Pizzinga, Mariavittoria
dc.contributor.author
Forte, Gabriela
dc.contributor.author
Griffin, Claire
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Garner, Kirsten E. L.
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Burt, Harriet E.
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Dixon, Hannah L.
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Hubbard, Simon
dc.contributor.author
Portela, Paula
dc.contributor.author
Ashe, Mark P.
dc.date.available
2022-10-14T17:56:09Z
dc.date.issued
2021-01
dc.identifier.citation
Morales Polanco, Fabian; Bates, Christian; Lui, Jennifer; Casson, Joseph; Solari, Clara Andrea; et al.; Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation; Cell Press; iScience; 24; 2; 1-2021; 1-36
dc.identifier.issn
2589-0042
dc.identifier.uri
http://hdl.handle.net/11336/173323
dc.description.abstract
Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and glycolytic enzymes are among the most abundant proteins in cells. Their expression at such levels provides a particular challenge. Here we demonstrate that the glycolytic mRNAs are localized to granules in yeast and human cells. Detailed live cell and smFISH studies in yeast show that the mRNAs are actively translated in granules, and this translation appears critical for the localization. Furthermore, this arrangement is likely to facilitate the higher level organization and control of the glycolytic pathway. Indeed, the degree of fermentation required by cells is intrinsically connected to the extent of mRNA localization to granules. On this basis, we term these granules, core fermentation (CoFe) granules; they appear to represent translation factories, allowing high-level coordinated enzyme synthesis for a critical metabolic pathway.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CELL BIOLOGY
dc.subject
MOLECULAR BIOLOGY
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-22T00:31:51Z
dc.journal.volume
24
dc.journal.number
2
dc.journal.pagination
1-36
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Morales Polanco, Fabian. University of Manchester; Reino Unido
dc.description.fil
Fil: Bates, Christian. University of Manchester; Reino Unido
dc.description.fil
Fil: Lui, Jennifer. University of Manchester; Reino Unido
dc.description.fil
Fil: Casson, Joseph. University of Manchester; Reino Unido
dc.description.fil
Fil: Solari, Clara Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Pizzinga, Mariavittoria. University of Manchester; Reino Unido
dc.description.fil
Fil: Forte, Gabriela. University of Manchester; Reino Unido
dc.description.fil
Fil: Griffin, Claire. University of Manchester; Reino Unido
dc.description.fil
Fil: Garner, Kirsten E. L.. University of Manchester; Reino Unido
dc.description.fil
Fil: Burt, Harriet E.. University of Manchester; Reino Unido
dc.description.fil
Fil: Dixon, Hannah L.. University of Manchester; Reino Unido
dc.description.fil
Fil: Hubbard, Simon. University of Manchester; Reino Unido
dc.description.fil
Fil: Portela, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Ashe, Mark P.. University of Manchester; Reino Unido
dc.journal.title
iScience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2589004221000377
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.isci.2021.102069
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