Artículo
Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation
Morales Polanco, Fabian; Bates, Christian; Lui, Jennifer; Casson, Joseph; Solari, Clara Andrea
; Pizzinga, Mariavittoria; Forte, Gabriela; Griffin, Claire; Garner, Kirsten E. L.; Burt, Harriet E.; Dixon, Hannah L.; Hubbard, Simon; Portela, Paula
; Ashe, Mark P.
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
01/2021
Editorial:
Cell Press
Revista:
iScience
ISSN:
2589-0042
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and glycolytic enzymes are among the most abundant proteins in cells. Their expression at such levels provides a particular challenge. Here we demonstrate that the glycolytic mRNAs are localized to granules in yeast and human cells. Detailed live cell and smFISH studies in yeast show that the mRNAs are actively translated in granules, and this translation appears critical for the localization. Furthermore, this arrangement is likely to facilitate the higher level organization and control of the glycolytic pathway. Indeed, the degree of fermentation required by cells is intrinsically connected to the extent of mRNA localization to granules. On this basis, we term these granules, core fermentation (CoFe) granules; they appear to represent translation factories, allowing high-level coordinated enzyme synthesis for a critical metabolic pathway.
Palabras clave:
CELL BIOLOGY
,
MOLECULAR BIOLOGY
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Morales Polanco, Fabian; Bates, Christian; Lui, Jennifer; Casson, Joseph; Solari, Clara Andrea; et al.; Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation; Cell Press; iScience; 24; 2; 1-2021; 1-36
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