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dc.contributor.author
Ratti, Silvia Gabriela
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dc.contributor.author
Sacchi, Osvaldo Jorge
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dc.contributor.author
Alvarez, Edgardo Oscar
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dc.date.available
2022-10-13T16:42:36Z
dc.date.issued
2021-03
dc.identifier.citation
Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo Oscar; Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat; Tsinghua University Press; Journal of Neurorestoratology; 9; 1; 3-2021; 72-80
dc.identifier.issn
2324-2426
dc.identifier.uri
http://hdl.handle.net/11336/173084
dc.description.abstract
In previous studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation and prepuberal stages of litters (F1 generation), the behavioural patterns of motivated exploration, lateralized exploration, social activity and survival responses of the maturing rats were modified. In order to find out if these affected behaviours should extend to the next generation, F1 litter rats, exposed previously to tellurium (Te) up to 30 days of age were left at rest with no further treatment up to reach 70 day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30 day-old preserved the modified behaviours previously observed in their parents. This evidence suggested that Te effects were intergenerational. In the present work, considering that in the first study ZnTe was used, and it is well known that Zn ion has many physiological functions in the cell, experiments were done in order to define if Zn could have a similar intergenerational effect than Te. Working with the same experimental setup than in previous experiments, but using ZnCl2 instead of ZnTe, results shown that none of the behavioural responses studied were affected in F1 generation. However, in F2 generation lateralized exploration and survival behaviour were inhibited, suggesting that Zn also has an intergenerational effect.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Tsinghua University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
LATERALITY
dc.subject
ZINC
dc.subject
TRACE ELEMENT
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-20T18:41:43Z
dc.journal.volume
9
dc.journal.number
1
dc.journal.pagination
72-80
dc.journal.pais
China
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dc.journal.ciudad
Beijing
dc.description.fil
Fil: Ratti, Silvia Gabriela. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; Argentina
dc.description.fil
Fil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Alvarez, Edgardo Oscar. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; Argentina
dc.journal.title
Journal of Neurorestoratology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2324242622000572
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.26599/JNR.2021.9040004
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