Artículo
Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
Fecha de publicación:
03/2021
Editorial:
Tsinghua University Press
Revista:
Journal of Neurorestoratology
ISSN:
2324-2426
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In previous studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation and prepuberal stages of litters (F1 generation), the behavioural patterns of motivated exploration, lateralized exploration, social activity and survival responses of the maturing rats were modified. In order to find out if these affected behaviours should extend to the next generation, F1 litter rats, exposed previously to tellurium (Te) up to 30 days of age were left at rest with no further treatment up to reach 70 day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30 day-old preserved the modified behaviours previously observed in their parents. This evidence suggested that Te effects were intergenerational. In the present work, considering that in the first study ZnTe was used, and it is well known that Zn ion has many physiological functions in the cell, experiments were done in order to define if Zn could have a similar intergenerational effect than Te. Working with the same experimental setup than in previous experiments, but using ZnCl2 instead of ZnTe, results shown that none of the behavioural responses studied were affected in F1 generation. However, in F2 generation lateralized exploration and survival behaviour were inhibited, suggesting that Zn also has an intergenerational effect.
Palabras clave:
LATERALITY
,
ZINC
,
TRACE ELEMENT
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Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo Oscar; Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat; Tsinghua University Press; Journal of Neurorestoratology; 9; 1; 3-2021; 72-80
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