Artículo
Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8 T-Cell Antiviral Activity and Correlates with Preservation of the CD4 TCell Compartment
Turk, Gabriela Julia Ana
; Ghiglione, Yanina Alexandra
; Falivene, Juliana
; Socias, María Eugenia; Laufer, Natalia Lorna
; Coloccini, Romina Soledad
; Rodríguez, Ana María
; Ruiz, María Julia; Pando, Maria de Los Angeles
; Giavedoni, Luis David; Cahn, Pedro; Sued, Omar Gustavo; Salomon, Horacio Eduardo
; Gherardi, Maria Magdalena
Fecha de publicación:
07/2013
Editorial:
American Society for Microbiology
Revista:
Journal of Virology
ISSN:
0022-538X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The important role of the CD8 T-cell response on HIV control is well established. Moreover, the acute phase of infection represents a proper scenario to delineate the antiviral cellular functions that best correlate with control. Here, multiple functional aspects (specificity, ex vivo viral inhibitory activity [VIA] and polyfunctionality) of the HIV-specific CD8 T-cell subset arising early after infection, and their association with disease progression markers, were examined. Blood samples from 44 subjects recruited within 6 months from infection (primary HIV infection [PHI] group), 16 chronically infected subjects, 11 elite controllers (EC), and 10 healthy donors were obtained. Results indicated that, although Nef dominated the anti-HIV response during acute/early infection, a higher proportion of early anti-Gag T cells correlated with delayed progression. Polyfunctional HIV-specific CD8 T cells were detected at early time points but did not associate with virus control. Conversely, higher CD4 T-cell set points were observed in PHI subjects with higher HIV-specific CD8 T-cell VIA at baseline. Importantly, VIA levels correlated with the magnitude of the anti-Gag cellular response. The advantage of Gag-specific cells may result from their enhanced ability to mediate lysis of infected cells (evidenced by a higher capacity to degranulate and to mediate VIA) and to simultaneously produce IFN-. Finally, Gag immunodominance was associated with elevated plasma levels of interleukin 2 (IL-2) and macrophage inflammatory protein 1 (MIP-1). All together, this study underscores the importance of CD8 T-cell specificity in the improved control of disease progression, which was related to the capacity of Gag-specific cells to mediate both lytic and nonlytic antiviral mechanisms at early time points postinfection.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Turk, Gabriela Julia Ana; Ghiglione, Yanina Alexandra; Falivene, Juliana; Socias, María Eugenia; Laufer, Natalia Lorna; et al.; Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8 T-Cell Antiviral Activity and Correlates with Preservation of the CD4 TCell Compartment; American Society for Microbiology; Journal of Virology; 87; 13; 7-2013; 7445-7462
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