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dc.contributor.author
Rascol, Olivier
dc.contributor.author
Negre Pages, Laurence
dc.contributor.author
Damier, Philippe
dc.contributor.author
Delval, Arnaud
dc.contributor.author
Derkinderen, Pascal
dc.contributor.author
Destée, Alain
dc.contributor.author
Fabbri, Margherita
dc.contributor.author
Meissner, Wassilios G.
dc.contributor.author
Rachdi, Amine
dc.contributor.author
Tison, Francois
dc.contributor.author
Perez Lloret, Santiago
dc.date.available
2022-09-27T12:05:15Z
dc.date.issued
2020-09
dc.identifier.citation
Rascol, Olivier; Negre Pages, Laurence; Damier, Philippe; Delval, Arnaud; Derkinderen, Pascal; et al.; Excessive buccal saliva in patients with Parkinson’s disease of the French COPARK cohort; Springer Wien; Journal of Neural Transmission. General Section; 127; 9-2020; 1607-1617
dc.identifier.issn
0300-9564
dc.identifier.uri
http://hdl.handle.net/11336/170565
dc.description.abstract
We describe excessive buccal saliva (EBS) prevalence in patients with Parkinson’s Disease (PD) and controls of the COPARK study, its changes between “ON” and OFF” conditions and over time, its impact on Health-related Quality of life (HRQoL), and factors associated with this condition. We studied 671 ambulatory PD patients and 177 age/sex-matched controls. We defined “sialorrhea” as UPDRS item #6 (salivation) = 1 or 2; and “drooling” as item #6 = 3 or 4. SCOPA-Aut drooling score (item #2) was also available in a subset (45%) of the cohort. HRQoL was assessed by the PDQ-39 and SF-36 scales. Twenty-four months’ follow-up data were available in 401/671 patients. EBS as assessed by UPDRS was present in 38% of PD patients in the “ON” condition (“Sialorrhea”: 35%; “drooling”: 3%). There were also more PD patients reporting “drooling” than controls according to the SCOPA-Aut (49% vs 19%, p < 0.01). UPDRS salivation score was worse in the “OFF” vs “ON” condition in PD patients with motor fluctuations (0.90 ± 0.94 vs 0.54 ± 0.79, p < 0.01). UPDRS salivation score worsened after ~ 24 months of follow-up (0.47 ± 0.70 vs 0.64 ± 0.81, p < 0.01). Worse PDQ-39 scores were observed in PD patients with EBS in bivariate but not in multivariate analyses. EBS was directly related to PD duration and severity, male gender, dysphagia, hypomimia, and autonomic dysfunction (logistic regression). EBS was more frequent in PD patients than controls, worsened in the “OFF” condition and after ~ 24 months of follow-up, moderately affected HRQoL, and was correlated with indices of bradykinesia, dysphagia, and autonomic dysfunction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Wien
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DROOLING
dc.subject
EXCESSIVE BUCCAL SALIVA
dc.subject
HEALTH-RELATED QUALITY OF LIFE
dc.subject
NON-MOTOR SYMPTOMS
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PARKINSON’S DISEASE
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SALIVA
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SIALORRHEA
dc.subject.classification
Neurología Clínica
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Excessive buccal saliva in patients with Parkinson’s disease of the French COPARK cohort
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-26T17:46:33Z
dc.journal.volume
127
dc.journal.pagination
1607-1617
dc.journal.pais
Austria
dc.journal.ciudad
Viena
dc.description.fil
Fil: Rascol, Olivier. Université de Toulouse; Francia. Inserm; Francia
dc.description.fil
Fil: Negre Pages, Laurence. Hôpital La Colombière; Francia
dc.description.fil
Fil: Damier, Philippe. Universite de Nantes; Francia. Inserm; Francia
dc.description.fil
Fil: Delval, Arnaud. Université de Lille; Francia. Inserm; Francia
dc.description.fil
Fil: Derkinderen, Pascal. Universite de Nantes; Francia. Inserm; Francia
dc.description.fil
Fil: Destée, Alain. Université de Lille; Francia. Inserm; Francia
dc.description.fil
Fil: Fabbri, Margherita. Università di Torino; Italia
dc.description.fil
Fil: Meissner, Wassilios G.. Universite de Bordeaux; Francia. Chu Hôpitaux de Bordeaux; Francia. University of Otago; Nueva Zelanda
dc.description.fil
Fil: Rachdi, Amine. Universite Paul Sabatier Toulouse; Francia. Inserm; Francia
dc.description.fil
Fil: Tison, Francois. Chu Hôpitaux de Bordeaux; Francia. Universite de Bordeaux; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Perez Lloret, Santiago. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Abierta Interamericana; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal of Neural Transmission. General Section
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00702-020-02249-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00702-020-02249-0
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