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dc.contributor.author
Santa Cruz, Iara Sofía
dc.contributor.author
Santa Cruz, Iara Sofía
dc.contributor.author
Garabalino, Marcela Alejandra
dc.contributor.author
Garabalino, Marcela Alejandra
dc.contributor.author
Trivillin, Verónica Andrea
dc.contributor.author
Trivillin, Verónica Andrea
dc.contributor.author
Itoiz, María Elina
dc.contributor.author
Itoiz, María Elina
dc.contributor.author
Pozzi, Emiliano César Cayetano
dc.contributor.author
Pozzi, Emiliano César Cayetano
dc.contributor.author
Thorp, Silvia Inés
dc.contributor.author
Thorp, Silvia Inés
dc.contributor.author
Curotto, Paula
dc.contributor.author
Curotto, Paula
dc.contributor.author
Guidobono, Juan Santiago
dc.contributor.author
Guidobono, Juan Santiago
dc.contributor.author
Heber, Elisa Mercedes
dc.contributor.author
Heber, Elisa Mercedes
dc.contributor.author
Nigg, David W.
dc.contributor.author
Nigg, David W.
dc.contributor.author
Schwint, Amanda Elena
dc.contributor.author
Schwint, Amanda Elena
dc.contributor.author
Monti Hughes, Andrea
dc.contributor.author
Monti Hughes, Andrea
dc.date.available
2022-09-15T11:49:55Z
dc.date.issued
2020-09
dc.date.issued
2020-09
dc.identifier.citation
Santa Cruz, Iara Sofía; Garabalino, Marcela Alejandra; Trivillin, Verónica Andrea; Itoiz, María Elina; Pozzi, Emiliano César Cayetano; et al.; Optimization of the classical oral cancerization protocol in hamster to study oral cancer therapy; Wiley Blackwell Publishing, Inc; Oral Diseases; 26; 6; 9-2020; 1-27
dc.identifier.citation
Santa Cruz, Iara Sofía; Garabalino, Marcela Alejandra; Trivillin, Verónica Andrea; Itoiz, María Elina; Pozzi, Emiliano César Cayetano; et al.; Optimization of the classical oral cancerization protocol in hamster to study oral cancer therapy; Wiley Blackwell Publishing, Inc; Oral Diseases; 26; 6; 9-2020; 1-27
dc.identifier.issn
1354-523X
dc.identifier.issn
1354-523X
dc.identifier.uri
http://hdl.handle.net/11336/168836
dc.description.abstract
Objective(s): The hamster carcinogenesis model recapitulates oral oncogenesis. Dimethylbenz[a]anthracene (DMBA) cancerization induces early severe mucositis, affecting animal's welfare and causing tissue loss and pouch shortening. “Short” pouches cannot be everted for local irradiation for boron neutron capture therapy (BNCT). Our aim was to optimize the DMBA classical cancerization protocol to avoid severe mucositis, without affecting tumor development. We evaluated BNCT in animals cancerized with this novel protocol. Materials and methods: We studied: Classical cancerization protocol (24 applications) and Classical with two interruptions (completed at the end of the cancerization protocol). BNCT mediated by boronophenylalanine (BPA) was performed in both groups. Results: The twice-interrupted group exhibited a significantly lower percentage of animals with severe mucositis versus the non-interrupted group (17% versus 71%) and a significantly higher incidence of long pouches (100% versus 53%). Tumor development and the histologic characteristics of tumor and precancerous tissue were not affected by the interruptions. For both groups, overall tumor response was more than 80%, with a similar incidence of BNCT-induced severe mucositis. Conclusion(s): The twice-interrupted protocol reduced severe mucositis during cancerization without affecting tumor development. This favored the animal's welfare and reduced the number of animals to be cancerized for our studies, without affecting BNCT response.
dc.description.abstract
Objective(s): The hamster carcinogenesis model recapitulates oral oncogenesis. Dimethylbenz[a]anthracene (DMBA) cancerization induces early severe mucositis, affecting animal's welfare and causing tissue loss and pouch shortening. “Short” pouches cannot be everted for local irradiation for boron neutron capture therapy (BNCT). Our aim was to optimize the DMBA classical cancerization protocol to avoid severe mucositis, without affecting tumor development. We evaluated BNCT in animals cancerized with this novel protocol. Materials and methods: We studied: Classical cancerization protocol (24 applications) and Classical with two interruptions (completed at the end of the cancerization protocol). BNCT mediated by boronophenylalanine (BPA) was performed in both groups. Results: The twice-interrupted group exhibited a significantly lower percentage of animals with severe mucositis versus the non-interrupted group (17% versus 71%) and a significantly higher incidence of long pouches (100% versus 53%). Tumor development and the histologic characteristics of tumor and precancerous tissue were not affected by the interruptions. For both groups, overall tumor response was more than 80%, with a similar incidence of BNCT-induced severe mucositis. Conclusion(s): The twice-interrupted protocol reduced severe mucositis during cancerization without affecting tumor development. This favored the animal's welfare and reduced the number of animals to be cancerized for our studies, without affecting BNCT response.
dc.format
application/pdf
dc.format
application/pdf
dc.language.iso
eng
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANIMAL WELFARE
dc.subject
ANIMAL WELFARE
dc.subject
BORON NEUTRON CAPTURE THERAPY
dc.subject
BORON NEUTRON CAPTURE THERAPY
dc.subject
CARCINOGENESIS
dc.subject
CARCINOGENESIS
dc.subject
HAMSTER CHEEK POUCH
dc.subject
HAMSTER CHEEK POUCH
dc.subject
MUCOSITIS
dc.subject
MUCOSITIS
dc.subject
ORAL CANCER
dc.subject
ORAL CANCER
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Optimization of the classical oral cancerization protocol in hamster to study oral cancer therapy
dc.title
Optimization of the classical oral cancerization protocol in hamster to study oral cancer therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-14T14:23:51Z
dc.identifier.eissn
1601-0825
dc.identifier.eissn
1601-0825
dc.journal.volume
26
dc.journal.volume
26
dc.journal.number
6
dc.journal.number
6
dc.journal.pagination
1-27
dc.journal.pagination
1-27
dc.journal.pais
Reino Unido
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.journal.ciudad
Londres
dc.description.fil
Fil: Santa Cruz, Iara Sofía. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Santa Cruz, Iara Sofía. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Garabalino, Marcela Alejandra. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Garabalino, Marcela Alejandra. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Thorp, Silvia Inés. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Thorp, Silvia Inés. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Curotto, Paula. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Curotto, Paula. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Guidobono, Juan Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.description.fil
Fil: Guidobono, Juan Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.description.fil
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Nigg, David W.. Idaho National Laboratory; Estados Unidos
dc.description.fil
Fil: Nigg, David W.. Idaho National Laboratory; Estados Unidos
dc.description.fil
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Monti Hughes, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Monti Hughes, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.journal.title
Oral Diseases
dc.journal.title
Oral Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13358
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13358
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/odi.13358
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/odi.13358
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