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dc.contributor.author
Ibanez Barassi, Agustin Mariano
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dc.contributor.author
Fittipaldi, Sol
dc.contributor.author
Trujillo, Catalina
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Jaramillo, Tania
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Torres, Alejandra
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Cardona, Juan F.
dc.contributor.author
Rivera, Rodrigo
dc.contributor.author
Slachevsky, Andrea
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Garciá, Adolfo
dc.contributor.author
Bertoux, Maxime
dc.contributor.author
Baez, Sandra
dc.date.available
2022-08-30T17:45:37Z
dc.date.issued
2021-08
dc.identifier.citation
Ibanez Barassi, Agustin Mariano; Fittipaldi, Sol; Trujillo, Catalina; Jaramillo, Tania; Torres, Alejandra; et al.; Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes; IOS Press; Journal of Alzheimer's Disease; 83; 1; 8-2021; 227-248
dc.identifier.issn
1387-2877
dc.identifier.uri
http://hdl.handle.net/11336/166974
dc.description.abstract
Background: Social cognition is critically compromised across neurodegenerative diseases, including the behavioral variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD). However, no previous study has used social cognition and other cognitive tasks to predict diagnoses of these conditions, let alone reporting the brain correlates of prediction outcomes. Objective: We performed a diagnostic classification analysis using social cognition, cognitive screening (CS), and executive function (EF) measures, and explored which anatomical and functional networks were associated with main predictors. Methods: Multiple group discriminant function analyses (MDAs) and ROC analyses of social cognition (facial emotional recognition, theory of mind), CS, and EF were implemented in 223 participants (bvFTD, AD, PD, controls). Gray matter volume and functional connectivity correlates of top discriminant scores were investigated. Results: Although all patient groups revealed deficits in social cognition, CS, and EF, our classification approach provided robust discriminatory characterizations. Regarding controls, probabilistic social cognition outcomes provided the best characterization for bvFTD (together with CS) and PD, but not AD (for which CS alone was the best predictor). Within patient groups, the best MDA probabilities scores yielded high classification rates for bvFTD versus PD (98.3%, social cognition), AD versus PD (98.6%, social cognition+CS), and bvFTD versus AD (71.7%, social cognition+CS). Top MDA scores were associated with specific patterns of atrophy and functional networks across neurodegenerative conditions. Conclusion: Standardized validated measures of social cognition, in combination with CS, can provide a dimensional classification with specific pathophysiological markers of neurodegeneration diagnoses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IOS Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CLASSIFICATION
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DEMENTIA
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DIAGNOSIS
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NEURODEGENERATIVE DISEASES
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SOCIAL COGNITION
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-16T18:05:24Z
dc.journal.volume
83
dc.journal.number
1
dc.journal.pagination
227-248
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ibanez Barassi, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile. Universidad de Dublin; Irlanda. University of California; Estados Unidos
dc.description.fil
Fil: Fittipaldi, Sol. Universidad Nacional de Córdoba; Argentina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Trujillo, Catalina. Universidad del Valle; Colombia
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Fil: Jaramillo, Tania. Universidad del Valle; Colombia
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Fil: Torres, Alejandra. Universidad del Valle; Colombia
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Fil: Cardona, Juan F.. Universidad del Valle; Colombia
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Fil: Rivera, Rodrigo. Universidad de Chile; Chile
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Fil: Slachevsky, Andrea. Universidad de Chile; Chile
dc.description.fil
Fil: Garciá, Adolfo. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Santiago de Chile; Chile. University of California; Estados Unidos
dc.description.fil
Fil: Bertoux, Maxime. Universidad Adolfo Ibañez; Chile
dc.description.fil
Fil: Baez, Sandra. Universidad de los Andes; Colombia
dc.journal.title
Journal of Alzheimer's Disease
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3233/JAD-210163
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210163
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