Artículo
Sex Reversal Syndrome in an Egyptian Arabian Horse Detected Using Genomic Data – A case report
Oliveira Nogueira, Pedro Paulo; de Almeida Gonçalves Amorim, Gabrielle Bueno; Marquez de Oliveira, Odilon; Demyda Peyrás, Sebastián
; Mendonça Santos, Bruna; Souza Lima Silveira da Mota, Lígia
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Fecha de publicación:
09/2021
Editorial:
Elsevier Science Inc.
Revista:
Journal of Equine Veterinary Science
ISSN:
0737-0806
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A 4-year-old Straight Egyptian Arabian horse was evaluated in 2016 due to a malformation of external genitalia and male sexual behavior. On physical examination, small teats in the inguinal area and a rudi- mentary penis-like structure surrounded by a clitoral fossa could be seen. There was no evidence of vulva and vaginal canal. A stallion like behavior was observed, especially in the presence of mares in heat, when the animal was excited and aggressive and had erection of the penis-like structure. Blood samples were collected for two purposes: hormonal (testosterone and estradiol plasma concentration analyses) and genetic (cytogenetic and molecular analysis). The karyotype showed 32 pairs of chromosomes in all cells (2n = 64) including 14 and 18 pairs of metacentric and acrocentric chromosomes respectively, in agreement with a presumptive 64, XX complement. This result agree with STR and SNP molecular analysis, which also ruled out the possibility of hematopoietic chimerism. In addition, SNP genotyping showed no numerical chromosomal aberrations or large deletions or duplications, that can be linked to the phenotype in any autosome, nor numerical chromosomal abnormalities in the father and mother of the horse analyzed. In conclusion, we determined that the animal in the present study is a male pseudo- hermaphrodite.
Palabras clave:
INTERSEXUAL
,
PSEUDOHERMAPHRODITE
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Oliveira Nogueira, Pedro Paulo; de Almeida Gonçalves Amorim, Gabrielle Bueno; Marquez de Oliveira, Odilon; Demyda Peyrás, Sebastián; Mendonça Santos, Bruna; et al.; Sex Reversal Syndrome in an Egyptian Arabian Horse Detected Using Genomic Data – A case report; Elsevier Science Inc.; Journal of Equine Veterinary Science; 104; 103692; 9-2021; 1-6
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