Mostrar el registro sencillo del ítem
dc.contributor.author
Hauser Davis, R.A.
dc.contributor.author
De Freitas, L. V.
dc.contributor.author
Cukierman, D. S.
dc.contributor.author
Cruz, W. S.
dc.contributor.author
Miotto, Marco César
dc.contributor.author
Fernandez, Claudio Oscar
dc.contributor.author
Valiente Gabioud, Ariel Alejandro
dc.contributor.author
Fernández, C. O.
dc.contributor.author
Rey, N. A.
dc.date.available
2022-07-29T22:21:37Z
dc.date.issued
2015-04
dc.identifier.citation
Hauser Davis, R.A.; De Freitas, L. V.; Cukierman, D. S.; Cruz, W. S.; Miotto, Marco César; et al.; Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?; Royal Society of Chemistry; Metallomics; 7; 5; 4-2015; 743-747
dc.identifier.issn
1756-5901
dc.identifier.uri
http://hdl.handle.net/11336/163597
dc.description.abstract
Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg-1, showing potential as an anti-Alzheimer's drug.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Alzheimer
dc.subject
Zinc
dc.subject
Copper
dc.subject
Therapy
dc.subject.classification
Química Inorgánica y Nuclear
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:40:36Z
dc.journal.volume
7
dc.journal.number
5
dc.journal.pagination
743-747
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Hauser Davis, R.A.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
dc.description.fil
Fil: De Freitas, L. V.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
dc.description.fil
Fil: Cukierman, D. S.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
dc.description.fil
Fil: Cruz, W. S.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
dc.description.fil
Fil: Miotto, Marco César. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Fernandez, Claudio Oscar. Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Valiente Gabioud, Ariel Alejandro. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Fernández, C. O.. Laboratorio Max Planck de Biología Estructural, Química y Biofísica Molecular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.description.fil
Fil: Rey, N. A.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
dc.journal.title
Metallomics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c5mt00003c
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/metallomics/article/7/5/743/6015152
Archivos asociados
Tamaño:
1.619Mb
Formato:
PDF