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dc.contributor.author
Taggart Murphy, Laura
dc.contributor.author
Alama Bermejo, Gema
dc.contributor.author
Dolan, Brian
dc.contributor.author
Takizawa, Fumio
dc.contributor.author
Bartholomew, Jerri
dc.date.available
2022-06-29T04:33:54Z
dc.date.issued
2021-01
dc.identifier.citation
Taggart Murphy, Laura; Alama Bermejo, Gema; Dolan, Brian; Takizawa, Fumio; Bartholomew, Jerri; Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta; Elsevier; Developmental And Comparative Immunology; 114; 103829; 1-2021; 1-8
dc.identifier.issn
0145-305X
dc.identifier.uri
http://hdl.handle.net/11336/160703
dc.description.abstract
Two genotypes of the intestinal parasite Ceratonova shasta infect Oncorhynchus mykiss: genotype 0 results in a chronic infection with low mortality while genotype IIR causes disease with high mortality. We determined parasite load and the relative expression of six immune factors (IgT, IgM, IL-6, IL-8, IL-10, IFNG) in fish infected with either genotype over 29 days post-exposure. In genotype IIR infections the host responded with upregulation of inflammatory and regulatory cytokines. In contrast, genotype 0 infection did not elicit an inflammatory response and expression of IFNG and IL-10 was lower. Antibody expression was upregulated in both infections but appeared to have limited efficacy in the virulent genotype IIR infections. Histologically, in genotype 0 infections the parasite migrated through the tissue layers causing inflammation but minimal damage to the mucosal epithelium, which contrasts with the severe pathology found in genotype IIR infections.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CYTOKINE
dc.subject
FISH DISEASE
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IMMUNOGLOBULIN
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INTESTINE
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SALMONID
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Otros Tópicos Biológicos
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-26T17:24:35Z
dc.journal.volume
114
dc.journal.number
103829
dc.journal.pagination
1-8
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Taggart Murphy, Laura. State University of Oregon; Estados Unidos. University of Oregon; Estados Unidos
dc.description.fil
Fil: Alama Bermejo, Gema. State University of Oregon; Estados Unidos. Biology Center of the Czech Academy of Sciences; República Checa
dc.description.fil
Fil: Dolan, Brian. State University of Oregon; Estados Unidos
dc.description.fil
Fil: Takizawa, Fumio. Fukui Prefectural University; Japón
dc.description.fil
Fil: Bartholomew, Jerri. State University of Oregon; Estados Unidos
dc.journal.title
Developmental And Comparative Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.dci.2020.103829
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0145305X20303840
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