Artículo
Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta
Fecha de publicación:
01/2021
Editorial:
Elsevier
Revista:
Developmental And Comparative Immunology
ISSN:
0145-305X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Two genotypes of the intestinal parasite Ceratonova shasta infect Oncorhynchus mykiss: genotype 0 results in a chronic infection with low mortality while genotype IIR causes disease with high mortality. We determined parasite load and the relative expression of six immune factors (IgT, IgM, IL-6, IL-8, IL-10, IFNG) in fish infected with either genotype over 29 days post-exposure. In genotype IIR infections the host responded with upregulation of inflammatory and regulatory cytokines. In contrast, genotype 0 infection did not elicit an inflammatory response and expression of IFNG and IL-10 was lower. Antibody expression was upregulated in both infections but appeared to have limited efficacy in the virulent genotype IIR infections. Histologically, in genotype 0 infections the parasite migrated through the tissue layers causing inflammation but minimal damage to the mucosal epithelium, which contrasts with the severe pathology found in genotype IIR infections.
Palabras clave:
CYTOKINE
,
FISH DISEASE
,
IMMUNOGLOBULIN
,
INTESTINE
,
SALMONID
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Articulos(CIMAS)
Articulos de CENTRO DE INVESTIGACION APLICADA Y TRANSFERENCIA TECNOLOGICA EN RECURSOS MARINOS "ALMIRANTE STORNI"
Articulos de CENTRO DE INVESTIGACION APLICADA Y TRANSFERENCIA TECNOLOGICA EN RECURSOS MARINOS "ALMIRANTE STORNI"
Citación
Taggart Murphy, Laura; Alama Bermejo, Gema; Dolan, Brian; Takizawa, Fumio; Bartholomew, Jerri; Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta; Elsevier; Developmental And Comparative Immunology; 114; 103829; 1-2021; 1-8
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