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dc.contributor.author
Tshweu, Lesego
dc.contributor.author
Katata, Lebogang
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Kalombo, Lonji
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Chiappetta, Diego Andrés
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Höcht, Christian
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Sosnik, Alejandro Dario
dc.contributor.author
Swai, Hulda
dc.date.available
2017-05-03T21:21:44Z
dc.date.issued
2014-11
dc.identifier.citation
Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Chiappetta, Diego Andrés; Höcht, Christian; et al.; Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method; Future Medicine; Nanomedicine; 9; 12; 11-2014; 1821-1833
dc.identifier.issn
1743-5889
dc.identifier.uri
http://hdl.handle.net/11336/15949
dc.description.abstract
AIM: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. MATERIALS & METHODS: EFV-loaded PCL NPs were produced by a double-emulsion/spray-drying method. RESULTS: NPs displayed a hydrodynamic diameter of 200-250 nm. The encapsulation efficiency was 86-93% and the mass recovery was above 60%. X-ray diffraction indicated that drug and PCL underwent amorphization during the spray-drying process. Encapsulation within NPs significantly increased the maximum concentration in plasma and the bioavailability. CONCLUSION: EFV-loaded PCL NPs represent a promising platform to develop scalable pharmaceuticals with improved (bio)pharmaceutic performance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Future Medicine
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hiv
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Efavirenz
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In Vitro Drug Release
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Oral Bioavailability
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Poly (Epsilon-Caprolactone)
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Spray Drying
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Otras Nanotecnología
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-26T14:13:27Z
dc.journal.volume
9
dc.journal.number
12
dc.journal.pagination
1821-1833
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Tshweu, Lesego. Council for Scientific & Industrial
Research; Sudáfrica
dc.description.fil
Fil: Katata, Lebogang. North-West University. Faculty of Agriculture, Science & Technology. Chemistry Department; Sudáfrica. Council for Scientific & Industrial
Research; Sudáfrica
dc.description.fil
Fil: Kalombo, Lonji. Council for Scientific & Industrial
Research; Sudáfrica
dc.description.fil
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
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Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Technion - Israel Institute of Technology; Israel
dc.description.fil
Fil: Swai, Hulda. Council for Scientific & Industrial
Research; Sudáfrica
dc.journal.title
Nanomedicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/10.2217/nnm.13.167
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2217/nnm.13.167
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