Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method

Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Chiappetta, Diego Andrés; Höcht, Christian; Sosnik, Alejandro Dario; Swai, Hulda

doi:10.2217/nnm.13.167

Artículo

Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method

Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Chiappetta, Diego Andrés Icon

; Höcht, Christian; Sosnik, Alejandro Dario Icon

; Swai, Hulda

Fecha de publicación: 11/2014

Editorial: Future Medicine

Revista: Nanomedicine

ISSN: 1743-5889

Idioma: Inglés

Tipo de recurso: Artículo publicado

Clasificación temática:

Otras Nanotecnología

Resumen

AIM: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. MATERIALS & METHODS: EFV-loaded PCL NPs were produced by a double-emulsion/spray-drying method. RESULTS: NPs displayed a hydrodynamic diameter of 200-250 nm. The encapsulation efficiency was 86-93% and the mass recovery was above 60%. X-ray diffraction indicated that drug and PCL underwent amorphization during the spray-drying process. Encapsulation within NPs significantly increased the maximum concentration in plasma and the bioavailability. CONCLUSION: EFV-loaded PCL NPs represent a promising platform to develop scalable pharmaceuticals with improved (bio)pharmaceutic performance.

Palabras clave: Hiv , Efavirenz , In Vitro Drug Release , Oral Bioavailability , Poly (Epsilon-Caprolactone) , Spray Drying

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/15949

URL: http://www.futuremedicine.com/doi/10.2217/nnm.13.167

DOI: http://dx.doi.org/10.2217/nnm.13.167

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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Citación

Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Chiappetta, Diego Andrés; Höcht, Christian; et al.; Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method; Future Medicine; Nanomedicine; 9; 12; 11-2014; 1821-1833

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