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dc.contributor.author
Talevi, Alan  
dc.contributor.author
Bellera, Carolina Leticia  
dc.contributor.other
Talevi, Alan  
dc.date.available
2022-06-10T15:18:21Z  
dc.date.issued
2021  
dc.identifier.citation
Talevi, Alan; Bellera, Carolina Leticia; Free drug theory; Springer; 2021; 1-6  
dc.identifier.isbn
978-3-030-51519-5  
dc.identifier.uri
http://hdl.handle.net/11336/159479  
dc.description.abstract
The free drug theory (sometimes also termed free drug hypothesis) provides a conceptual framework increasingly used to understand pharmacokinetics/pharmacodynamics (PK/PD) relationships [1]. It underlines the central role of free (or unbound) drug concentration at the site of action (the surroundings of the drug target) as determinant of in vivo efficacy and pharmacokinetics. A deep understanding of this theory can also be helpful to establish in vitro-in vivo correlations or, alternatively, to provide explanations to absence of clear correlations between in vitro and in vivo studies.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
FREE DRUG THEORY  
dc.subject
UNBOUND DRUG  
dc.subject
PLASMA PROTEIN BINDING  
dc.subject
TISSUE BINDING  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Free drug theory  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2022-04-26T20:19:22Z  
dc.journal.pagination
1-6  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Basignstoke  
dc.description.fil
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina  
dc.description.fil
Fil: Bellera, Carolina Leticia. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/978-3-030-51519-5_51-1  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/referenceworkentry/10.1007%2F978-3-030-51519-5_51-1  
dc.conicet.paginas
1500  
dc.source.titulo
The ADME encyclopedia: A comprehensive guide on biopharmacy and pharmacokinetics  

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