Artículo
Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
Vera, María Inés; Meroño, Tomás
; Urrutia, María Agustina; Parisi, Carina; Morosan, Yanina; Rosmarin, Melanie; Schnitman, Marta; Brites, Fernando Daniel
; Grisendi, Silvio; Serrano, María Sol; Luciani, Wilfredo; Serrano, Leonardo; Zuk, Carlos; de Barrio, Guillermo; Cejas, Claudia; Faingold, María Cristina; Brenta, Gabriela
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
05/2014
Editorial:
Hindawi Publishing Corporation
Revista:
Journal of Thyroid Research
ISSN:
2042-0072
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Objective. Ultrasonographic characteristics are associated with thyroid malignancy. Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules. Methods. We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy. Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo. Associations were separately assessed in mixed and solid nodules. Results. In a group of 504 elderly female patients (age = years), the frequency of malignant cytology was 6%. Thirty-one percent of nodules were mixed and 60% were solid. The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, : 0.56). While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all ). The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25–6.10), : 0.012). Conclusions. Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules. Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules.
Palabras clave:
Thyroid Nodules
,
Ultrasonographic
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Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Vera, María Inés; Meroño, Tomás; Urrutia, María Agustina; Parisi, Carina; Morosan, Yanina; et al.; Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population; Hindawi Publishing Corporation; Journal of Thyroid Research; 2014; 5-2014; 1-7
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