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dc.contributor.author
Carusela, María Florencia
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dc.contributor.author
Rubi, J. Miguel
dc.date.available
2022-05-19T14:19:43Z
dc.date.issued
2021-02-22
dc.identifier.citation
Carusela, María Florencia; Rubi, J. Miguel; Computational model for membrane transporters: Potential implications for cancer; Frontiers Media; Frontiers in Cell and Developmental Biology; 9; 642665; 22-2-2021; 1-6
dc.identifier.uri
http://hdl.handle.net/11336/157824
dc.description.abstract
To explain the increased transport of nutrients and metabolites and to control the movement of drug molecules through the transporters to the cancer cells, it is important to understand the exact mechanism of their structure and activity, as well as their biological and physical characteristics. We propose a computational model that reproduces the functionality of membrane transporters by quantifying the flow of substrates through the cell membrane. The model identifies the force induced by conformational changes of the transporter due to hydrolysis of ATP, in ABC transporters, or by an electrochemical gradient of ions, in secondary transporters. The transport rate is computed by averaging the velocity generated by the force along the paths followed by the substrates. The results obtained are in accordance with the experiments. The model provides an overall framework for analyzing the membrane transport proteins that regulate the flows of ions, nutrients and other molecules across the cell membranes, and their activities.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Cancer transporters
dc.subject
Membrane transport mechanisms
dc.subject
Entropic forces
dc.subject
Langevin equation
dc.subject
Cancer therapies
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Computational model for membrane transporters: Potential implications for cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-09T20:31:03Z
dc.identifier.eissn
2296-634X
dc.journal.volume
9
dc.journal.number
642665
dc.journal.pagination
1-6
dc.journal.pais
Suiza
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dc.journal.ciudad
Lausanne
dc.description.fil
Fil: Carusela, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
dc.description.fil
Fil: Rubi, J. Miguel. Universidad de Barcelona; España
dc.journal.title
Frontiers in Cell and Developmental Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fcell.2021.642665
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2021.642665/full
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