Artículo
Computational model for membrane transporters: Potential implications for cancer
Fecha de publicación:
22/02/2021
Editorial:
Frontiers Media
Revista:
Frontiers in Cell and Developmental Biology
e-ISSN:
2296-634X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
To explain the increased transport of nutrients and metabolites and to control the movement of drug molecules through the transporters to the cancer cells, it is important to understand the exact mechanism of their structure and activity, as well as their biological and physical characteristics. We propose a computational model that reproduces the functionality of membrane transporters by quantifying the flow of substrates through the cell membrane. The model identifies the force induced by conformational changes of the transporter due to hydrolysis of ATP, in ABC transporters, or by an electrochemical gradient of ions, in secondary transporters. The transport rate is computed by averaging the velocity generated by the force along the paths followed by the substrates. The results obtained are in accordance with the experiments. The model provides an overall framework for analyzing the membrane transport proteins that regulate the flows of ions, nutrients and other molecules across the cell membranes, and their activities.
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Citación
Carusela, María Florencia; Rubi, J. Miguel; Computational model for membrane transporters: Potential implications for cancer; Frontiers Media; Frontiers in Cell and Developmental Biology; 9; 642665; 22-2-2021; 1-6
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