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Artículo

Lemon oils attenuate the pathogenicity of pseudomonas aeruginosa by quorum sensing inhibition

Luciardi, María ConstanzaIcon ; Blázquez, María Amparo; Alberto, Maria RosaIcon ; Cartagena, Elena; Arena, Mario EduardoIcon
Fecha de publicación: 05/2021
Editorial: Molecular Diversity Preservation International
Revista: Molecules
ISSN: 1420-3049
e-ISSN: 1420-3049
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

The chemical composition of three Citrus limon oils: lemon essential oil (LEO), lemon terpenes (LT) and lemon essence (LE), and their influence in the virulence factors production and motility (swarming and swimming) of two Pseudomonas aeruginosa strains (ATCC 27853 and a multidrug-resistant HT5) were investigated. The main compound, limonene, was also tested in biological assays. Eighty-four compounds, accounting for a relative peak area of 99.23%, 98.58% and 99.64%, were identified by GC/MS. Limonene (59–60%), γ-terpinene (10–11%) and β-pinene (7–15%) were the main compounds. All lemon oils inhibited specific biofilm production and bacterial metabolic activities into biofilm in a dose-dependent manner (20–65%, in the range of 0.1–4 mg mL−1) of both strains. Besides, all samples inhibited about 50% of the elastase activity at 0.1 mg mL−1. Pyocyanin biosynthesis decreases until 64% (0.1–4 mg mL−1) for both strains. Swarming motility of P. aeruginosa ATCC 27853 was completely inhibited by 2 mg mL−1 of lemon oils. Furthermore, a decrease (29–55%, 0.1–4 mg mL−1) in the synthesis of Quorum sensing (QS) signals was observed. The oils showed higher biological activities than limonene. Hence, their ability to control the biofilm of P. aeruginosa and reduce the production of virulence factors regulated by QS makes lemon oils good candidates to be applied as preservatives in the food processing industry.
Palabras clave: BIOFILM , CITRUS PEEL , ELASTASE , MOTILITY , PYOCYANIN , QUORUM SENSING , VIRULENCE FACTORS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/153903
DOI: http://dx.doi.org/10.3390/molecules26102863
URL: https://www.mdpi.com/1420-3049/26/10/2863
Colecciones
Articulos(INBIOFAL)
Articulos de INSTITUTO DE BIOTECNOLOGÍA FARMACEUTICA Y ALIMENTARIA
Citación
Luciardi, María Constanza; Blázquez, María Amparo; Alberto, Maria Rosa; Cartagena, Elena; Arena, Mario Eduardo; Lemon oils attenuate the pathogenicity of pseudomonas aeruginosa by quorum sensing inhibition; Molecular Diversity Preservation International; Molecules; 26; 10; 5-2021; 1-14;2863
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