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dc.contributor.author
Aprile García, Fernando
dc.contributor.author
Antunica Noguerol, María de Las Nieves
dc.contributor.author
Budziñski, Maia Ludmila
dc.contributor.author
Liberman, Ana Clara
dc.contributor.author
Arzt, Eduardo Simon
dc.date.available
2015-07-31T16:51:51Z
dc.date.issued
2013-12
dc.identifier.citation
Aprile García, Fernando; Antunica Noguerol, María de Las Nieves; Budziñski, Maia Ludmila; Liberman, Ana Clara; Arzt, Eduardo Simon; Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1; BioScientifica Ltd; Endocrine Connections; 1; 12-2013; 1-12
dc.identifier.issn
2049-3614
dc.identifier.uri
http://hdl.handle.net/11336/1530
dc.description.abstract
Inflammatory responses are elicited after injury, involving release of inflammatory mediators that ultimately lead, at the molecular level, to the activation of specific transcription factors (TFs; mainly activator protein 1 and nuclear factor-kB). These TFs propagate inflammation by inducing the expression of cytokines and chemokines. The neuroendocrine system has a determinant role in the maintenance of homeostasis, to avoid exacerbated inflammatory responses. Glucocorticoids (GCs) are the key neuroendocrine regulators of the inflammatory response. In this study, we describe the molecular mechanisms involved in the interplay between inflammatory cytokines, the neuroendocrine axis and GCs necessary for the control of inflammation. Targeting and modulation of the glucocorticoid receptor (GR) and its activity is a common therapeutic strategy to reduce pathological signaling. Poly (ADP-ribose)polymerase 1 (PARP1) is an enzyme that catalyzes the addition of PAR on target proteins,a post-translational modification termed PARylation. PARP1 has a central role in transcriptional regulation of inflammatory mediators, both in neuroendocrine tumors and in CNS cells. It is also involved in modulation of several nuclear receptors. Therefore, PARP1 and GR share common inflammatory pathways with antagonic roles in the control of inflammatory processes, which are crucial for the effective maintenance of homeostasis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioScientifica Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Neuroendocrinology
dc.subject
Inflammation
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Glucocorticoid Receptor (Gr)
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Poly (Adp-Ribose) Polymerase 1 (Parp1)
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
1
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
dc.journal.ciudad
Bristol
dc.description.fil
Fil: Aprile García, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Conicet -; Instituto P; Argentina
dc.description.fil
Fil: Antunica Noguerol, María de Las Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Conicet -; Instituto P; Argentina
dc.description.fil
Fil: Budziñski, Maia Ludmila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Conicet -; Instituto P; Argentina
dc.description.fil
Fil: Liberman, Ana Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Conicet -; Instituto P; Argentina
dc.description.fil
Fil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Conicet -; Instituto P; Argentina
dc.journal.title
Endocrine Connections
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.endocrineconnections.com/content/3/1/R1.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/EC-13-0079
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/24243533
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