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Artículo

Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1

Aprile García, FernandoIcon ; Antunica Noguerol, María de Las NievesIcon ; Budziñski, Maia Ludmila; Liberman, Ana ClaraIcon ; Arzt, Eduardo SimonIcon
Fecha de publicación: 12/2013
Editorial: BioScientifica Ltd
Revista: Endocrine Connections
ISSN: 2049-3614
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Inflammatory responses are elicited after injury, involving release of inflammatory mediators that ultimately lead, at the molecular level, to the activation of specific transcription factors (TFs; mainly activator protein 1 and nuclear factor-kB). These TFs propagate inflammation by inducing the expression of cytokines and chemokines. The neuroendocrine system has a determinant role in the maintenance of homeostasis, to avoid exacerbated inflammatory responses. Glucocorticoids (GCs) are the key neuroendocrine regulators of the inflammatory response. In this study, we describe the molecular mechanisms involved in the interplay between inflammatory cytokines, the neuroendocrine axis and GCs necessary for the control of inflammation. Targeting and modulation of the glucocorticoid receptor (GR) and its activity is a common therapeutic strategy to reduce pathological signaling. Poly (ADP-ribose)polymerase 1 (PARP1) is an enzyme that catalyzes the addition of PAR on target proteins,a post-translational modification termed PARylation. PARP1 has a central role in transcriptional regulation of inflammatory mediators, both in neuroendocrine tumors and in CNS cells. It is also involved in modulation of several nuclear receptors. Therefore, PARP1 and GR share common inflammatory pathways with antagonic roles in the control of inflammatory processes, which are crucial for the effective maintenance of homeostasis.
Palabras clave: Neuroendocrinology , Inflammation , Glucocorticoid Receptor (Gr) , Poly (Adp-Ribose) Polymerase 1 (Parp1)
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/1530
URL: http://www.endocrineconnections.com/content/3/1/R1.long
DOI: http://dx.doi.org/10.1530/EC-13-0079
URL: http://www.ncbi.nlm.nih.gov/pubmed/24243533
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Aprile García, Fernando; Antunica Noguerol, María de Las Nieves; Budziñski, Maia Ludmila; Liberman, Ana Clara; Arzt, Eduardo Simon; Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1; BioScientifica Ltd; Endocrine Connections; 1; 12-2013; 1-12
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