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dc.contributor.author
Bottasso, Oscar Adelmo
dc.contributor.author
Bay, Maria Luisa
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Besedovsky, Hugo
dc.contributor.author
del Rey, Adriana
dc.date.available
2017-04-12T20:17:25Z
dc.date.issued
2013-03
dc.identifier.citation
Bottasso, Oscar Adelmo; Bay, Maria Luisa; Besedovsky, Hugo; del Rey, Adriana; Adverse neuro-immune–endocrine interactions in patients with active tuberculosis; Elsevier Inc; Molecular And Cellular Neurosciences.; 53; 3-2013; 77-85
dc.identifier.issn
1044-7431
dc.identifier.uri
http://hdl.handle.net/11336/15247
dc.description.abstract
The nervous, endocrine and immune systems play a crucial role in maintaining homeostasis and interact with each other for a successful defensive strategy against injurious agents. However, the situation is different in long-term diseases with marked inflammation, in which defensive mechanisms become altered. In the case of tuberculosis (TB), this is highlighted by several facts: an imbalance of plasma immune and endocrine mediators, that results in an adverse environment for mounting an adequate response against mycobacteria and controlling inflammation; the demonstration that dehidroepiandrosterone (DHEA) secretion by a human adrenal cell line can be inhibited by culture supernatants from Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells – PBMC – of TB patients, with this effect being partly reverted when neutralizing transforming growth factor-β in such supernantants; the in vitro effects of adrenal steroids on the specific immune response of PBMC from TB patients, that is a cortisol inhibition of mycobacterial antigen-driven lymphoproliferation and interferon-γ production as well as a suppression of TGF-β production in DHEA-treated PBMC; and lastly the demonstration that immune and endocrine compounds participating in the regulation of energy sources and immune activity correlated with the consumption state of TB patients. Collectively, immune-endocrine disturbances of TB patients are involved in critical components of disease pathology with implications in the impaired clinical status and unfavorable disease outcome. This article is part of a Special Issue entitled ‘Neuroinflammation in neurodegeneration and neurodysfunction’.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Tuberculosis
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Neuroscience
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Immune-Endocrine Interactions
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Regulation
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Sistema Respiratorio
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Adverse neuro-immune–endocrine interactions in patients with active tuberculosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-12T17:57:47Z
dc.journal.volume
53
dc.journal.pagination
77-85
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
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Fil: Besedovsky, Hugo. Institute für Physiologie und Pathophysiologie; Alemania
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Fil: del Rey, Adriana. Institute für Physiologie und Pathophysiologie; Alemania
dc.journal.title
Molecular And Cellular Neurosciences.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mcn.2012.11.002
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1044743112002011
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