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Artículo

Adverse neuro-immune–endocrine interactions in patients with active tuberculosis

Bottasso, Oscar AdelmoIcon ; Bay, Maria Luisa; Besedovsky, Hugo; del Rey, Adriana
Fecha de publicación: 03/2013
Editorial: Elsevier Inc
Revista: Molecular And Cellular Neurosciences.
ISSN: 1044-7431
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Sistema Respiratorio

Resumen

The nervous, endocrine and immune systems play a crucial role in maintaining homeostasis and interact with each other for a successful defensive strategy against injurious agents. However, the situation is different in long-term diseases with marked inflammation, in which defensive mechanisms become altered. In the case of tuberculosis (TB), this is highlighted by several facts: an imbalance of plasma immune and endocrine mediators, that results in an adverse environment for mounting an adequate response against mycobacteria and controlling inflammation; the demonstration that dehidroepiandrosterone (DHEA) secretion by a human adrenal cell line can be inhibited by culture supernatants from Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells – PBMC – of TB patients, with this effect being partly reverted when neutralizing transforming growth factor-β in such supernantants; the in vitro effects of adrenal steroids on the specific immune response of PBMC from TB patients, that is a cortisol inhibition of mycobacterial antigen-driven lymphoproliferation and interferon-γ production as well as a suppression of TGF-β production in DHEA-treated PBMC; and lastly the demonstration that immune and endocrine compounds participating in the regulation of energy sources and immune activity correlated with the consumption state of TB patients. Collectively, immune-endocrine disturbances of TB patients are involved in critical components of disease pathology with implications in the impaired clinical status and unfavorable disease outcome. This article is part of a Special Issue entitled ‘Neuroinflammation in neurodegeneration and neurodysfunction’.
Palabras clave: Tuberculosis , Neuroscience , Immune-Endocrine Interactions , Regulation
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/15247
DOI: http://dx.doi.org/10.1016/j.mcn.2012.11.002
URL: http://www.sciencedirect.com/science/article/pii/S1044743112002011
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Bottasso, Oscar Adelmo; Bay, Maria Luisa; Besedovsky, Hugo; del Rey, Adriana; Adverse neuro-immune–endocrine interactions in patients with active tuberculosis; Elsevier Inc; Molecular And Cellular Neurosciences.; 53; 3-2013; 77-85
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