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dc.contributor.author
Mangano, A.
dc.contributor.author
Kopka, J.
dc.contributor.author
Batalla, M.
dc.contributor.author
Bologna, R.
dc.contributor.author
Sen, Luisa
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dc.date.available
2021-12-20T20:48:46Z
dc.date.issued
2000-01
dc.identifier.citation
Mangano, A.; Kopka, J.; Batalla, M.; Bologna, R.; Sen, Luisa; Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection; Lippincott Williams; Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology; 23; 1; 1-2000; 52-57
dc.identifier.issn
1525-4135
dc.identifier.uri
http://hdl.handle.net/11336/149060
dc.description.abstract
The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3'A), CCR2-64I, and CCR5-Δ32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We have investigated whether these polymorphisms may provide similar beneficial effects in children exposed to HIV-1 perinatally. The prevalence of CCR2-64I allele was significantly increased (p = .03) and the CCR2-64I genotype distribution was not in Hardy-Weinberg equilibrium, among HIV-1-exposed uninfected infants. Moreover, in the HIV-1- infected group, a delay to AIDS progression was observed among carriers of CCR2-64I allele. This is the first report that suggests a protective role of CCR2-64I allele in mother-to-infant HIV-1 transmission and documents a delay in disease progression, after the child has been infected with HIV-1. However, SDF1-3'A and CCR5-Δ32 alleles did not modify the rate of HIV-1 transmission or disease progression in HIV-1-infected children.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CCR2
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CCR5
dc.subject
CHEMOKINE RECEPTORS
dc.subject
HIV-1
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PEDIATRIC AIDS
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SDF1
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VERTICAL TRANSMISSION
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-12-20T17:24:58Z
dc.identifier.eissn
1077-9450
dc.journal.volume
23
dc.journal.number
1
dc.journal.pagination
52-57
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Mangano, A.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Kopka, J.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Batalla, M.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Bologna, R.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/jaids/Abstract/2000/01010/Protective_Effect_of_CCR2_64I_and_Not_of_CCR5__32.7.aspx
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/00126334-200001010-00007
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