Artículo
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection
Fecha de publicación:
01/2000
Editorial:
Lippincott Williams
Revista:
Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology
ISSN:
1525-4135
e-ISSN:
1077-9450
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3'A), CCR2-64I, and CCR5-Δ32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We have investigated whether these polymorphisms may provide similar beneficial effects in children exposed to HIV-1 perinatally. The prevalence of CCR2-64I allele was significantly increased (p = .03) and the CCR2-64I genotype distribution was not in Hardy-Weinberg equilibrium, among HIV-1-exposed uninfected infants. Moreover, in the HIV-1- infected group, a delay to AIDS progression was observed among carriers of CCR2-64I allele. This is the first report that suggests a protective role of CCR2-64I allele in mother-to-infant HIV-1 transmission and documents a delay in disease progression, after the child has been infected with HIV-1. However, SDF1-3'A and CCR5-Δ32 alleles did not modify the rate of HIV-1 transmission or disease progression in HIV-1-infected children.
Palabras clave:
CCR2
,
CCR5
,
CHEMOKINE RECEPTORS
,
HIV-1
,
PEDIATRIC AIDS
,
SDF1
,
VERTICAL TRANSMISSION
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Mangano, A.; Kopka, J.; Batalla, M.; Bologna, R.; Sen, Luisa; Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection; Lippincott Williams; Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology; 23; 1; 1-2000; 52-57
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