Artículo

The radical-based reduction with (TMS)3SiH 'on water'

Postigo, Jose AlbertoIcon ; Ferreri, Carla; Navacchia, Maria Luisa; Chatgilialoglu, Chryssostomos
Fecha de publicación: 12/2005
Editorial: Georg Thieme Verlag Kg
Revista: Synlett
ISSN: 0936-5214
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Reduction of different organohalides, bromonucleosides among them, was successfully carried out in yields ranging from 75% to quantitative, using (TMS)3SiH in a heterogeneous system with water as the solvent. Our procedure, employing 2-mercaptoethanol as the catalyst and the hydrophobic diazo-compound ACCN as the initiator, illustrates that (TMS)3SiH can be the radical-based reducing agent of choice in aqueous medium. (TMS) 3SiH does not suffer from any significant reaction with water and can safely be used with additional benefit, such as ease of purification and environmental compatibility.
Palabras clave: AZO COMPOUNDS , RADICAL REACTIONS , REDUCTIONS , THIOLS , TRIS(TRIMETHYLSILYL)SILANE
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/147592
URL: https://www.thieme-connect.com/ejournals/abstract/synlett/doi/10.1055/s-2005-918
DOI: http://dx.doi.org/10.1055/s-2005-918917
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Postigo, Jose Alberto; Ferreri, Carla; Navacchia, Maria Luisa; Chatgilialoglu, Chryssostomos; The radical-based reduction with (TMS)3SiH 'on water'; Georg Thieme Verlag Kg; Synlett; 18; 12-2005; 2854-2856
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