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dc.contributor.author Lopez Bergami, Pablo Roberto
dc.contributor.author Kim, Hyungsoo
dc.contributor.author Dewing, Antimone
dc.contributor.author Goydos, James
dc.contributor.author Aaronson, Stuart
dc.contributor.author Ronai, Ze´ev
dc.date.available 2017-04-03T15:54:25Z
dc.date.issued 2010-01-08
dc.identifier.citation Lopez Bergami, Pablo Roberto; Kim, Hyungsoo ; Dewing, Antimone ; Goydos, James ; Aaronson, Stuart; et al.; c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis; American Society For Biochemistry And Molecular Biology; Journal Of Biological Chemistry; 285; 2; 8-1-2010; 903-913
dc.identifier.issn 0021-9258
dc.identifier.uri http://hdl.handle.net/11336/14682
dc.description.abstract utations in N-RAS and B-RAF, which commonly occur in melanomas, result in constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) signaling. Active ERK increases expression and activity of the c-Jun transcription factor, linking ERK and Jun N-terminal kinase (JNK) cascades. Here, we show that c-Jun regulates transcription of phosphoinositide-dependent kinase 1 (PDK1) with a concomitant impact on Akt and protein kinase C (PKC) activity and related substrates. Inhibition of c-Jun reduces PDK1 expression and attenuates Akt and PKC activity, which can be restored by exogenous PDK1. c-Jun regulation of PDK1 in melanoma contributes to growth rate and the ability to form tumors in mice. Correspondingly, increased levels of c-Jun in melanoma cell lines coincide with up-regulation of PDK1 and phosphorylation of PKC and Akt. The identification of c-Jun as a transcriptional regulator of PDK1 expression highlights key mechanisms underlying c-Jun oncogenic activity, and provides new insight into the nature of up-regulated Akt and PKC in melanoma.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Society For Biochemistry And Molecular Biology
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject MELANOMA
dc.subject CANCER
dc.subject GENE EXPRESSION REGULATION
dc.subject NEOPLASM TRANSPLANTATION
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Otras Medicina Básica
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-03-23T18:22:37Z
dc.identifier.eissn 1083-351X
dc.journal.volume 285
dc.journal.number 2
dc.journal.pagination 903-913
dc.journal.pais Estados Unidos
dc.journal.ciudad Baltimore
dc.description.fil Fil: Lopez Bergami, Pablo Roberto. The Burnham Institute for Medical Research; Estados Unidos. Mount Sinai School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
dc.description.fil Fil: Kim, Hyungsoo . The Burnham Institute for Medical Research; Estados Unidos
dc.description.fil Fil: Dewing, Antimone . The Burnham Institute for Medical Research; Estados Unidos
dc.description.fil Fil: Goydos, James . Robert Wood Johnson Medical School; Estados Unidos
dc.description.fil Fil: Aaronson, Stuart. Mount Sinai School of Medicine; Estados Unidos
dc.description.fil Fil: Ronai, Ze´ev. The Burnham Institute for Medical Research; Estados Unidos
dc.journal.title Journal Of Biological Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/285/2/903
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1074/jbc.M109.075630
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801291/


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)