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dc.contributor.author
Salas Silva, Soraya
dc.contributor.author
Simoni Nieves, Arturo
dc.contributor.author
Razori, María Valeria
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dc.contributor.author
López Ramirez, Jocelyn
dc.contributor.author
Barrera Chimal, Jonatan
dc.contributor.author
Lazzarini, Roberto
dc.contributor.author
Bello, Oscar
dc.contributor.author
Souza, Verónica
dc.contributor.author
Miranda Labra, Roxana U.
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Gutiérrez Ruiz, María Concepción
dc.contributor.author
Gomez Quiroz, Luis Enrique
dc.contributor.author
Roma, Marcelo Gabriel
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dc.contributor.author
Bucio Ortiz, Leticia
dc.date.available
2021-10-29T15:37:01Z
dc.date.issued
2020-04
dc.identifier.citation
Salas Silva, Soraya; Simoni Nieves, Arturo; Razori, María Valeria; López Ramirez, Jocelyn; Barrera Chimal, Jonatan; et al.; HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress; Pergamon-Elsevier Science Ltd; Biochemical Pharmacology; 174; 4-2020; 1-13
dc.identifier.issn
0006-2952
dc.identifier.uri
http://hdl.handle.net/11336/145481
dc.description.abstract
Cholestasis is a clinical syndrome common to a large number of hepatopathies, in which either bile production or its transit through the biliary tract is impaired due to functional or obstructive causes; the consequent intracellular retention of toxic biliary constituents generates parenchyma damage, largely via oxidative stress-mediated mechanisms. Hepatocyte growth factor (HGF) and its receptor c-Met represent one of the main systems for liver repair damage and defense against hepatotoxic factors, leading to an antioxidant and repair response. In this study, we evaluated the capability of HGF to counteract the damage caused by the model cholestatic agent, α-naphthyl isothiocyanate (ANIT). HGF had clear anti-cholestatic effects, as apparent from the improvement in both bile flow and liver function test. Histology examination revealed a significant reduction of injured areas. HGF also preserved the tight-junctional structure. These anticholestatic effects were associated with the induction of basolateral efflux ABC transporters, which facilitates extrusion of toxic biliary compounds and its further alternative depuration via urine. The biliary epithelium seems to have been also preserved, as suggested by normalization in serum GGT levels, CFTR expression and cholangyocyte primary cilium structure our results clearly show for the first time that HGF protects the liver from a cholestatic injury.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANIT
dc.subject
CHOLESTASIS
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HGF
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LIVER
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OXIDATIVE STRESS
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:42:46Z
dc.journal.volume
174
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Salas Silva, Soraya. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Simoni Nieves, Arturo. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Razori, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
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Fil: López Ramirez, Jocelyn. Universidad Autónoma Metropolitana; México
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Fil: Barrera Chimal, Jonatan. Universidad Nacional Autónoma de México; México
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Fil: Lazzarini, Roberto. Universidad Autónoma Metropolitana; México
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Fil: Bello, Oscar. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Souza, Verónica. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Miranda Labra, Roxana U.. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Gutiérrez Ruiz, María Concepción. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Gomez Quiroz, Luis Enrique. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Roma, Marcelo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
dc.description.fil
Fil: Bucio Ortiz, Leticia. Universidad Autónoma Metropolitana; México
dc.journal.title
Biochemical Pharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bcp.2020.113812
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0006295220300228?via%3Dihub
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