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dc.contributor.author Choi, Marcelo Roberto
dc.contributor.author Lee, Brenda M.
dc.contributor.author Medici, Cecilia
dc.contributor.author Correa, Alicia H.
dc.contributor.author Fernandez, Belisario Enrique
dc.date.available 2017-03-29T23:39:19Z
dc.date.issued 2010-04
dc.identifier.citation Choi, Marcelo Roberto; Lee, Brenda M.; Medici, Cecilia; Correa, Alicia H.; Fernandez, Belisario Enrique; Effects of angiotensin II on renal dopamine metabolism: synthesis, release, catabolism and turnover; Karger; Nephron Physiology; 115; 1; 4-2010; 1-7
dc.identifier.uri http://hdl.handle.net/11336/14493
dc.description.abstract Background/Aims: Dopamine (DA) uptake inhibition in the renal cortex, elicited by angiotensin II (ANG II), is mediated by AT1 receptors and signals through the phospholipase C pathway and activation of protein kinase C and CaM-kinase II. By this indirect way, ANG II stimulates renal Na+,K+-ATPase activity through DA intracellular reduction. In the present work, we continued to study different aspects of renal DA metabolism in DA-ANG II interaction, such as DA synthesis, release, catabolism and turnover. Methods: ANG II effects on DA synthesis, release, catabolism and turnover were measured in samples from the outer renal cortex of Sprague-Dawley rats. Results: ANG II reduced renal aromatic acid decarboxylate activity without affecting basal secretion of DA or its KCl-induced release. Moreover, ANG II enhanced monoamine oxidase activity without altering catechol-o-methyl transferase activity and increased DA turnover. Conclusion: Current results as well as previous findings show that ANG II modifies DA metabolism in rat renal cortex by reducing DA uptake, decreasing DA synthesis enzyme activity and increasing monoamine oxidase activity, and DA turnover. Together, all these effects may reduce DA accumulation into renal cells and decrease its endogenous content and availability. This would prevent D1 receptor recruitment and stimulation, while diminishing DA inhibition of Na+,K+-ATPase activity and stimulating sodium reabsorption.
dc.format application/pdf
dc.language.iso eng
dc.publisher Karger
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject angiotensin II
dc.subject dopamine
dc.subject kidney
dc.subject renal cortex
dc.subject.classification Fisiología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Effects of angiotensin II on renal dopamine metabolism: synthesis, release, catabolism and turnover
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-03-21T20:13:46Z
dc.identifier.eissn 1660-2137
dc.journal.volume 115
dc.journal.number 1
dc.journal.pagination 1-7
dc.journal.pais Suiza
dc.journal.ciudad Basilea
dc.description.fil Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Lee, Brenda M.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Medici, Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Correa, Alicia H.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title Nephron Physiology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.karger.com/Article/Abstract/311522
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000311522


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)