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Artículo

Effects of angiotensin II on renal dopamine metabolism: synthesis, release, catabolism and turnover

Choi, Marcelo RobertoIcon ; Lee, Brenda M.; Medici, Cecilia; Correa, Alicia H.; Fernandez, Belisario EnriqueIcon
Fecha de publicación: 04/2010
Editorial: Karger
Revista: Nephron Physiology
e-ISSN: 1660-2137
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

Background/Aims: Dopamine (DA) uptake inhibition in the renal cortex, elicited by angiotensin II (ANG II), is mediated by AT1 receptors and signals through the phospholipase C pathway and activation of protein kinase C and CaM-kinase II. By this indirect way, ANG II stimulates renal Na+,K+-ATPase activity through DA intracellular reduction. In the present work, we continued to study different aspects of renal DA metabolism in DA-ANG II interaction, such as DA synthesis, release, catabolism and turnover. Methods: ANG II effects on DA synthesis, release, catabolism and turnover were measured in samples from the outer renal cortex of Sprague-Dawley rats. Results: ANG II reduced renal aromatic acid decarboxylate activity without affecting basal secretion of DA or its KCl-induced release. Moreover, ANG II enhanced monoamine oxidase activity without altering catechol-o-methyl transferase activity and increased DA turnover. Conclusion: Current results as well as previous findings show that ANG II modifies DA metabolism in rat renal cortex by reducing DA uptake, decreasing DA synthesis enzyme activity and increasing monoamine oxidase activity, and DA turnover. Together, all these effects may reduce DA accumulation into renal cells and decrease its endogenous content and availability. This would prevent D1 receptor recruitment and stimulation, while diminishing DA inhibition of Na+,K+-ATPase activity and stimulating sodium reabsorption.
Palabras clave: Angiotensin Ii , Dopamine , Kidney , Renal Cortex
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/14493
URL: http://www.karger.com/Article/Abstract/311522
DOI: http://dx.doi.org/10.1159/000311522
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Choi, Marcelo Roberto; Lee, Brenda M.; Medici, Cecilia; Correa, Alicia H.; Fernandez, Belisario Enrique; Effects of angiotensin II on renal dopamine metabolism: synthesis, release, catabolism and turnover; Karger; Nephron Physiology; 115; 1; 4-2010; 1-7
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