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dc.contributor.author
Baldeyron, Céline
dc.contributor.author
Soria, Ramiro Gaston
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dc.contributor.author
Cook, Adam J. L.
dc.contributor.author
Almouzni, Geneviève
dc.date.available
2017-03-29T19:25:35Z
dc.date.issued
2011-04
dc.identifier.citation
Baldeyron, Céline; Soria, Ramiro Gaston; Cook, Adam J. L.; Almouzni, Geneviève; HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair; Rockefeller Univ Press; Journal Of Cell Biology; 193; 1; 4-2011; 81-95
dc.identifier.issn
0021-9525
dc.identifier.uri
http://hdl.handle.net/11336/14468
dc.description.abstract
Heterochromatin protein 1 (HP1), a major component of constitutive heterochromatin, is recruited to DNA damage sites. However, the mechanism involved in this recruitment and its functional importance during DNA repair remain major unresolved issues. Here, by characterizing HP1α dynamics at laser-induced damage sites in mammalian cells, we show that the de novo accumulation of HP1α occurs within both euchromatin and heterochromatin as a rapid and transient event after DNA damage. This recruitment is strictly dependent on p150CAF-1, the largest subunit of chromatin assembly factor 1 (CAF-1), and its ability to interact with HP1α. We find that HP1α depletion severely compromises the recruitment of the DNA damage response (DDR) proteins 53BP1 and RAD51. Moreover, HP1α depletion leads to defects in homologous recombination-mediated repair and reduces cell survival after DNA damage. Collectively, our data reveal that HP1α recruitment at early stages of the DDR involves p150CAF-1 and is critical for proper DNA damage signaling and repair.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Rockefeller Univ Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hp1
dc.subject
Caf-1
dc.subject
Dna Repair
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-27T17:42:07Z
dc.journal.volume
193
dc.journal.number
1
dc.journal.pagination
81-95
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Baldeyron, Céline. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Soria, Ramiro Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Institute Curie; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Cook, Adam J. L.. Centre National de la Recherche Scientifique; Francia. Institute Curie; Francia
dc.description.fil
Fil: Almouzni, Geneviève. Centre National de la Recherche Scientifique; Francia. Institute Curie; Francia
dc.journal.title
Journal Of Cell Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jcb.rupress.org/content/193/1/81.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1083/jcb.201101030
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