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Artículo

HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

Baldeyron, Céline; Soria, Ramiro GastonIcon ; Cook, Adam J. L.; Almouzni, Geneviève
Fecha de publicación: 04/2011
Editorial: Rockefeller Univ Press
Revista: Journal Of Cell Biology
ISSN: 0021-9525
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Heterochromatin protein 1 (HP1), a major component of constitutive heterochromatin, is recruited to DNA damage sites. However, the mechanism involved in this recruitment and its functional importance during DNA repair remain major unresolved issues. Here, by characterizing HP1α dynamics at laser-induced damage sites in mammalian cells, we show that the de novo accumulation of HP1α occurs within both euchromatin and heterochromatin as a rapid and transient event after DNA damage. This recruitment is strictly dependent on p150CAF-1, the largest subunit of chromatin assembly factor 1 (CAF-1), and its ability to interact with HP1α. We find that HP1α depletion severely compromises the recruitment of the DNA damage response (DDR) proteins 53BP1 and RAD51. Moreover, HP1α depletion leads to defects in homologous recombination-mediated repair and reduces cell survival after DNA damage. Collectively, our data reveal that HP1α recruitment at early stages of the DDR involves p150CAF-1 and is critical for proper DNA damage signaling and repair.
Palabras clave: Hp1 , Caf-1 , Dna Repair
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/14468
URL: http://jcb.rupress.org/content/193/1/81.long
DOI: http://dx.doi.org/10.1083/jcb.201101030
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Baldeyron, Céline; Soria, Ramiro Gaston; Cook, Adam J. L.; Almouzni, Geneviève; HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair; Rockefeller Univ Press; Journal Of Cell Biology; 193; 1; 4-2011; 81-95
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